Document Detail

Blood pressure sensitivity to salt in rats with low urinary kallikrein excretion.
MedLine Citation:
PMID:  8856169     Owner:  NLM     Status:  MEDLINE    
We evaluated if a rat strain inbred for reduced urinary kallikrein excretion differs from normal-kallikrein Wistar rats regarding blood pressure in basal conditions and during alterations in sodium balance. Low-kallikrein rats showed greater systolic blood pressure values (125 +/- 3 vs. 114 +/- 2 mmHg in controls, P < 0.01) at 9 weeks of age. Systolic blood pressure was increased after 20 days of dietary sodium loading in the low-kallikrein group and remained unchanged in controls (150 +/- 6 vs. 112 +/- 2 mmHg, P < 0.01) and this effect was associated with a reduced cumulative excretion of sodium (23% less in the low-kallikrein group compared with controls, P < 0.01). Urinary creatinine excretion was decreased by sodium loading in both groups, and this effect was more pronounced in the low-kallikrein group. The group-difference in urinary kallikrein excretion found in basal conditions (2.49 +/- 0.10 vs. 7.78 +/- 0.53 Pkat/100 g body weight, P < 0.01) was enhanced by high salt diet (1.05 +/- 0.21 vs. 8.31 +/- 0.70 Pkat/100 g body weight, P < 0.01). The ratio of heart weight to body weight was significantly greater in low-kallikrein rats (331 +/- 7 vs. 275 +/- 4 mg/100 g body weight, P < 0.01), whereas the ratio of kidney weight to body weight was lower (329 +/- 5 vs. 370 +/- 8 mg/100 body weight, P < 0.01). Our results indicate that a genetically-determined defect in urinary kallikrein excretion is associated with a greater blood pressure sensitivity to salt, possibly due to altered renal sodium handling.
P Madeddu; M V Varoni; M P Demontis; P Pinna-Parpaglia; N Glorioso; V Anania
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Immunopharmacology     Volume:  33     ISSN:  0162-3109     ISO Abbreviation:  Immunopharmacology     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1997-02-10     Completed Date:  1997-02-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902474     Medline TA:  Immunopharmacology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  301-4     Citation Subset:  IM    
Clinica Medica and Farmacologia, University of Sassari, Italy.
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MeSH Terms
Blood Pressure / drug effects*,  physiology
Drug Resistance
Hypertension / etiology,  physiopathology
Kallikrein-Kinin System / physiology
Kallikreins / urine*
Kidney / physiology
Natriuresis / physiology
Rats, Inbred Strains
Rats, Wistar
Sodium Chloride / pharmacology*
Species Specificity
Reg. No./Substance:
7647-14-5/Sodium Chloride; EC 3.4.21.-/Kallikreins

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