Document Detail

Blood pressure and risk of cardiovascular diseases in type 2 diabetes: further findings from the Swedish National Diabetes Register (NDR-BP II).
MedLine Citation:
PMID:  22871895     Owner:  NLM     Status:  Publisher    
OBJECTIVES:: Estimate risks of coronary heart disease (CHD), stroke and cardiovascular disease (CVD) with updated mean systolic (SBP) and diastolic (DBP) blood pressure in an observational study of patients with type 2 diabetes. METHODS:: Thirty-five thousand and forty-one patients treated with antihypertensive drugs, and 18 512 untreated patients, aged 30-75 years, without previous heart failure, followed for 6 years until 2009. RESULTS:: In treated patients, nonlinear splines for 6-year risk of fatal/nonfatal CHD, stroke and CVD by BP as a continuous variable showed a progressive increase with higher SBP from 140 mmHg and higher, and with DBP from 80 mmHg, with a J-shaped risk curve at lowest SBP levels, but not obviously at lowest DBP levels. Analysing intervals of SBP with 130-134 mmHg as reference at Cox regression, adjusted hazard ratios (HR) for fatal/nonfatal CHD, stroke and CVD with at least 140 mmHg were 1.22 [95% confidence interval (CI): 1.08-1.39], 1.43 (1.18-1.72), 1.26 (1.13-1.41), all P < 0.001. HR with 115-129 and 135-139 mmHg were nonsignificant, whereas increased with 100-114 mmHg, 1.96 (P < 0.001), 1.75 (P = 0.02), 2.08 (P < 0.001), respectively. With DBP 75-79 mmHg as reference, adjusted HR for fatal/nonfatal CHD, stroke and CVD with DBP 80-84 mmHg were 1.42 (1.26-1.59), 1.46 (1.24-1.72), 1.39 (1.26-1.53), all P < 0.001. Corresponding HR with DBP at least 85 mmHg were 1.70 (1.50-1.92), 2.35 (1.99-2.77), 1.87 (1.69-2.07), all P < 0.001. Corresponding HR with DBP 60-69 and 70-74 mmHg were nonsignificant. The picture was similar in 7059 patients with previous CVD and in untreated patients. CONCLUSION:: BP around 130-135/75-79 mmHg showed lower risks of cardiovascular diseases in patients with type 2 diabetes.
Jan Cederholm; Soffia Gudbjörnsdottir; Björn Eliasson; Björn Zethelius; Katarina Eeg-Olofsson; Peter M Nilsson;
Related Documents :
13495 - Mode of action of beta blockers in angina pectoris.
6363365 - Effects of physical training on adrenergic sensitivity in obesity.
2463975 - Blood pressure, heart rate, and heart rhythm changes in patients with heart disease dur...
7256285 - Cerebroventricular propranolol elevates cerebrospinal fluid norepinephrine and lowers b...
1562045 - Two faces of sympathetic nervous activity--hypotension and hypertension.
21610385 - A modified model of the abdominal compartment syndrome.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-4
Journal Detail:
Title:  Journal of hypertension     Volume:  -     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aDepartment of Public Health and Caring Sciences/Family Medicine and Clinical Epidemiology, Uppsala University, Uppsala bDepartment of Medicine, Sahlgrenska University Hospital, Gothenburgh University, Göteborg cDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, and Medical Products Agency, Uppsala dDepartment of Clinical Sciences, Lund University, University Hospital, Malmö, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The great myth of office blood pressure measurement.
Next Document:  Weakly nonlinear analysis of symmetry breaking in cell polarity models.