Document Detail

Blood pressure responses to substances interfering with nitric oxide formation, cyclooxygenase and converting enzyme activities and vasopressin V1 receptors blockade in conscious spontaneously hypertensive and normotensive rats.
MedLine Citation:
PMID:  8000447     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to investigate to what extent inhibition of nitric oxide (NO) formation, cyclooxygenase and converting enzyme activities and vasopressin V1 receptors blockade affects the cardiovascular system in conscious, freely moving normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. The experiments were performed on 33 WKY and on 33 SHR. In series 1 (8 WKY and 8 SHR) animals received bolus injection of N omega-nitro-L-arginine - NLA (10 mg/kg), in series 2 (6 WKY and 6 SHR) bolus injection of indomethacin (10 mg/kg). In series 3 (8 WKY and 8 SHR) the animals received captopril as initial bolus (1 mg/kg) followed by constant infusion (1 mg/kg/min), in series 4 (11 WKY and 11 SHR) vasopressin V1 receptor antagonist 1-(1-mercapto-4-methylcyclohexaneacetic acid)-8-arginine-vasopressin (MeCAAVP) was infused (1.52 micrograms/kg/min). In series 1 in WKY NLA elicited a long-lasting, significant increase in mean blood pressure (max 46 +/- 3 mmHg at 40 min). In SHR mean blood pressure raises were not significant (max 22 +/- 6 mmHg). In series 2, both in WKY and SHR, indomethacin elicited only transient, nonsignificant increases in mean blood pressure. In series 3, the mean blood pressure fall during the captopril infusion was more pronounced in SHR than in WKY (45 +/- 2 mmHg vs 13 +/- 2 mmHg respectively). In series 4 vasopressin V1 receptor blockade caused a nonsignificant fall in mean blood pressure, both in WKY and SHR.(ABSTRACT TRUNCATED AT 250 WORDS)
A Januszewicz; M Lapiński; T Styś; A Styś; S Loń
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Polish journal of pharmacology     Volume:  46     ISSN:  1230-6002     ISO Abbreviation:  Pol J Pharmacol     Publication Date:    1994 May-Jun
Date Detail:
Created Date:  1995-01-25     Completed Date:  1995-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9313882     Medline TA:  Pol J Pharmacol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  153-61     Citation Subset:  IM    
Department of Hypertension and Angiology, Medical Academy, Warszawa, Poland.
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MeSH Terms
Analysis of Variance
Angiotensin-Converting Enzyme Inhibitors / pharmacology*,  therapeutic use
Arginine / analogs & derivatives,  pharmacology
Arginine Vasopressin / analogs & derivatives,  pharmacology,  therapeutic use
Blood Pressure / drug effects*
Body Weight / drug effects
Captopril / pharmacology,  therapeutic use
Cyclooxygenase Inhibitors / pharmacology*,  therapeutic use
Disease Models, Animal
Heart Rate / drug effects
Hypertension / drug therapy*
Indomethacin / pharmacology,  therapeutic use
Nitric Oxide / antagonists & inhibitors*,  biosynthesis
Rats, Inbred SHR
Rats, Inbred WKY
Receptors, Vasopressin / antagonists & inhibitors*
Renin-Angiotensin System / drug effects
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Cyclooxygenase Inhibitors; 0/Receptors, Vasopressin; 10102-43-9/Nitric Oxide; 113-79-1/Arginine Vasopressin; 119617-71-9/argipressin, (1-mercapto-4-methylcyclohexaneacetic acid)(1)-; 2149-70-4/Nitroarginine; 53-86-1/Indomethacin; 62571-86-2/Captopril; 74-79-3/Arginine

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