| Blood pressure responses to ACTH and adrenaline infusions in dogs. | |
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MedLine Citation:
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PMID: 2988827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hypothesis that interactions between adrenaline and adrenal cortical hormones may increase arterial blood pressure has been examined in trained dogs with chronically indwelling aortic and venous catheters. The dogs received continuous infusions for 4 days of ACTH (400 micrograms/day), or adrenaline (8 mg/day) or both ACTH and adrenaline, or saline vehicle. Compared to pre-infusion control values, ACTH raised mean arterial pressure by 14.9 +/- 2.2 mmHg by the 4th day of infusion, adrenaline infused alone had no effect (-0.2 +/- 3.9 mmHg), and ACTH and adrenaline infused together raised pressure 13.1 +/- 3.2 mmHg (not significantly different to ACTH alone). ACTH increased water consumption, Na+ and K+ excretion and creatinine clearance by the 4th day of infusion and these effects were not significantly altered when adrenaline was also infused. Thus adrenaline did not potentiate the hypertension produced by ACTH administration. |
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Authors:
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W P Anderson; D E Ramsey |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental hypertension. Part A, Theory and practice Volume: 7 ISSN: 0730-0077 ISO Abbreviation: Clin Exp Hypertens A Publication Date: 1985 |
Date Detail:
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Created Date: 1985-08-12 Completed Date: 1985-08-12 Revised Date: 2008-02-12 |
Medline Journal Info:
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Nlm Unique ID: 8207790 Medline TA: Clin Exp Hypertens A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 525-37 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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pharmacology* Animals Blood Pressure / drug effects* Dogs Epinephrine / pharmacology* Glomerular Filtration Rate Heart Rate Potassium / metabolism Renin / blood Sodium / metabolism |
| Chemical | |
Reg. No./Substance:
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51-43-4/Epinephrine; 7440-09-7/Potassium; 7440-23-5/Sodium; 9002-60-2/Adrenocorticotropic Hormone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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