Document Detail


Blood pressure responses in young adults first exposed to high altitude for 12 months at 3550 m.
MedLine Citation:
PMID:  20039813     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the changes in blood pressure (BP) and related variables in sea-level young adults with chronic exposure to high altitude, a longitudinal study was performed in male army recruits (n = 346; age 17.9 +/- 0.1 yr; BMI, 22.5 +/- 0.3 kg/m(2)) first exposed to 3550-m altitude for 12 months. Fifty male recruits (age 17.8 +/- 0.6 and BMI 22.6 +/- 0.3 kg/m(2)) never exposed to altitude were used as controls. A sustained higher mean diastolic BP (DBP) (82.1 +/- 1.0 mmHg at month 3; 81.3 +/- 0.9 mmHg at month 12) was observed, compared to first exposure and the control group (p < 0.001). The BP values were always higher than those of the sea-level control group (systolic blood pressure (SBP) 109 +/- 2.3 and DBP 67.4 +/- 0.8; p < 0.001), and a large proportion of subjects steadily presented overoptimal values for either systolic BP (SBP) (64%) or DBP (77%) and hypertensive DBP values (40%). The higher DBP was associated with lower Sao(2) (OR = 0.919; p < 0.05). In addition, the acute mountain sickness (AMS) score showed a slight decrease during re-exposure (3.9 +/- 0.3 vs.3.4 +/- 0.3; p < 0.001) and an inverse association to the before-descending Sao(2) at month 3 (OR = 0.906, p < 0.01). These data suggest that BP stabilization can take longer than currently thought and that each parameter has a different profile of change. Further, a sustained high DBP should be a matter of epidemiological concern and emphasizes the need for BP monitoring among young lowlanders exposed to high altitude.
Authors:
Patricia Siqu?s; Julio Brito; Jose R Banegas; Fabiola Le?n-Velarde; Juan J de la Cruz-Troca; Vasthi L?pez; Nelson Naveas; Rafael Herruzo
Related Documents :
7670973 - Metabolic and hemodynamic responses to walking with shoulder-worn exercise weights: a b...
11206673 - Inverse association of chlamydia pneumoniae infection with high blood pressure in japan...
12392843 - Left ventricular pressure-volume relationship in a murine model of congestive heart fai...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  High altitude medicine & biology     Volume:  10     ISSN:  1557-8682     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-30     Completed Date:  2010-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  329-35     Citation Subset:  IM; S    
Affiliation:
Institute of Health Studies, Universidad Arturo Prat , Iquique, Chile. psiques@tie.cl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acclimatization*
Adolescent
Altitude*
Altitude Sickness / physiopathology
Blood Pressure*
Body Mass Index
Heart Rate
Humans
Male
Oxygen / blood
Young Adult
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Do lung disease patients need supplemental oxygen at high altitude?
Next Document:  Immobilization and splinting in mountain rescue. Official Recommendations of the International Commi...