Document Detail


Blood pressure response to thermoregulatory vasoconstriction during isoflurane and desflurane anesthesia.
MedLine Citation:
PMID:  12859306     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Mild perioperative hypothermia produces morbid cardiac outcomes that may result from sympathetically induced hypertension. However, volatile anesthetics produce vasodilatation that may reduce the hemodynamic response to hypothermia. We tested the hypothesis that the volatile anesthetics isoflurane and desflurane blunt the normal cold-induced hypertensive response.
METHODS: We analyzed prospective data from three analogous studies: 1) 10 volunteers given desflurane (2.6 volume percentage) maintained in left-lateral position; 2) nine volunteers without anesthesia or anesthetized with various doses of desflurane; and 3) eight volunteers given various concentrations of isoflurane. Mean skin temperature was reduced to 31 C, which decreased core body temperature and triggered thermoregulatory vasoconstriction. Mean arterial pressures were determined before and after hypothermia provoked intense thermoregulatory vasoconstriction.
RESULTS: The hemodynamic responses to thermoregulatory vasoconstriction were similar without anesthesia and at all concentrations of desflurane and isoflurane. On average, mean arterial pressure increased 14 (SD = 5) mmHg with and without anesthesia.
CONCLUSION: We conclude that thermoregulatory vasoconstriction significantly increases arterial pressure with or without isoflurane or desflurane anesthesia.
Authors:
R Greif; S Laciny; A Rajek; A G Doufas; D I Sessler
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  47     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-15     Completed Date:  2004-01-29     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  847-52     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology and Intensive Care Medicine, Donauspital/SMZO, University of Vienna, Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, General
Anesthetics, Inhalation / pharmacology
Blood Pressure / drug effects*
Body Temperature Regulation / physiology*
Fingers / blood supply
Heart Rate / drug effects
Humans
Isoflurane / analogs & derivatives*,  pharmacology*
Male
Reference Values
Skin Temperature / drug effects
Vasoconstriction / physiology*
Grant Support
ID/Acronym/Agency:
GM 061655/GM/NIGMS NIH HHS; GM 58273/GM/NIGMS NIH HHS; R01 GM058273-04/GM/NIGMS NIH HHS; R01 GM061655-01A2/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 26675-46-7/Isoflurane; 57041-67-5/desflurane
Comments/Corrections

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