Document Detail


Blood pressure response to potassium supplementation is associated with genetic variation in endothelin 1 and interactions with E selectin in rural Chinese.
MedLine Citation:
PMID:  19996987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Although beneficial effects of potassium intake on blood pressure (BP) are well established, little is known about genetic factors that underlie interindividual variability in BP response to dietary potassium. In a previous study, we reported the first evidence for significant heritabilities for BP response in a dietary intervention study in rural Chinese. In this report, we extend our genetic studies to examine associations with polymorphisms in genes in vascular endothelial pathways.
METHODS: We genotyped study participants for 23 single nucleotide polymorphisms (SNPs) in endothelin 1 (EDN1), nitric oxide synthase 3, and E selectin (SELE). We tested 17 of these SNPs for associations with BP response to potassium supplementation in 1843 participants. Association tests used population-based [generalized estimation equation (GEE)] and family-based (quantitative transmission disequilibrium test) methods, as well as tests for gene-by-gene (GxG) interaction (generalized multifactor dimensionalilty reduction and GEE).
RESULTS: Single SNP analysis identified significant associations for several SNPs in EDN1 with multiple measures of BP response to potassium supplementation. The cumulative effects of the minor EDN1 alleles that showed significant associations were to reduce measures of BP response by 0.5-0.9 mmHg. We found significant evidence for effects of GxG interactions between EDN1 and SELE, even in the absence of individual associations with SELE variants.
CONCLUSION: Our results implicate variability in EDN1 and SELE as genetic factors that influence BP response to potassium intake. Although such epidemiological studies do not allow direct determination of physiologic mechanisms, our findings of joint effects identify EDN1 and SELE as targets for functional studies to determine their interactions in BP response to potassium intake.
Authors:
May E Montasser; Lawrence C Shimmin; Donfeng Gu; Jing Chen; Charles Gu; Tanika N Kelly; Cashell E Jaquish; Treva Rice; D C Rao; Jie Cao; Jichun Chen; De-Pei Liu; Paul Whelton; Jiang He; James E Hixson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  28     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-07-16     Completed Date:  2010-12-16     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  748-55     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Asian Continental Ancestry Group
Blood Pressure / genetics*,  physiology
China
E-Selectin / genetics
Endothelin-1 / genetics*
Epidemiologic Studies
Female
Genetic Variation*
Genotype
Humans
Male
Nitric Oxide Synthase Type III / genetics
Polymorphism, Single Nucleotide
Potassium, Dietary / administration & dosage,  pharmacology*
Rural Population / statistics & numerical data*
Grant Support
ID/Acronym/Agency:
R01 HL090682/HL/NHLBI NIH HHS; R01 HL090682-02/HL/NHLBI NIH HHS; U01HL072507/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/E-Selectin; 0/Endothelin-1; 0/Potassium, Dietary; EC 1.14.13.39/NOS3 protein, human; EC 1.14.13.39/Nitric Oxide Synthase Type III
Comments/Corrections
Comment In:
J Hypertens. 2010 Apr;28(4):668-70   [PMID:  20625248 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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