Document Detail


Blood pressure response to melatonin in type 1 diabetes.
MedLine Citation:
PMID:  15043687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HYPOTHESIS: Diminished decline of blood pressure at night has been associated with increased risk of cardiovascular disease. Exogenous melatonin given to healthy normotensive adults reduces blood pressure. We hypothesized that melatonin increases the decline of blood pressure during sleep in normotensive adolescents with type 1 diabetes. PATIENTS AND METHODS: Eleven normotensive normoalbuminuric patients with type 1 diabetes of 7.0 +/- 3.5 yr duration and 10 healthy controls aged 14-18 yr participated in a randomized placebo-controlled double-blind crossover study of 5 mg melatonin for 1 wk, with a 1-wk washout. Blood pressure was measured every 20 min for 24 h by an ambulatory device on the day before and on the last day of each treatment. Sleep measures were recorded by a diary and a wrist activity meter. Blood pressure measures were grouped by 24 h, sleep, and wake periods. Statistical analysis used sleep duration, number of awakenings, and treatment sequence as covariates for the blood pressure comparisons by treatment. RESULTS: In the patients with type 1 diabetes, the decline in diastolic blood pressure during sleep was significantly greater on melatonin (17.8 +/- 4.4 mmHg) than on placebo (16.0 +/- 3.0 mmHg, p < 0.01). No significant drug effect was present in the controls. No significant side effects were noted. CONCLUSION: Melatonin amplifies the nocturnal decline in diastolic blood pressure in patients with type 1 diabetes. We propose that dose-response studies of short- and long-acting preparations of melatonin be conducted and that melatonin be considered in trials of prevention of hypertension in type 1 diabetes.
Authors:
Anita Cavallo; Stephen R Daniels; Lawrence M Dolan; Jane C Khoury; Judy A Bean
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric diabetes     Volume:  5     ISSN:  1399-543X     ISO Abbreviation:  Pediatr Diabetes     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-26     Completed Date:  2004-11-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100939345     Medline TA:  Pediatr Diabetes     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  26-31     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Cincinnati College of Medicine and the Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA. anita.cavallo@cchmc.org
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects,  physiology*
Cross-Over Studies
Diabetes Mellitus, Type 1 / physiopathology*
Diastole / drug effects
Double-Blind Method
Female
Free Radical Scavengers / pharmacology
Humans
Male
Melatonin / pharmacology*
Sleep / drug effects
Systole / drug effects
Wakefulness / physiology
Grant Support
ID/Acronym/Agency:
RR-08084/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Free Radical Scavengers; 73-31-4/Melatonin

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