| Blood pressure response to hyperinsulinemia in salt-sensitive and salt-resistant rats. | |
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MedLine Citation:
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PMID: 1428109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the role of insulin in salt-sensitive hypertension in Dahl salt-sensitive and salt-resistant rats. The rats were kept in metabolic cages, and sodium intake and urinary sodium excretion were measured. In salt-sensitive rats receiving a 0.3% NaCl diet, sodium retention was significantly greater at weeks 1 and 2 in rats that received an insulin infusion than in those receiving a saline infusion. Mean arterial blood pressure and plasma norepinephrine levels were significantly higher at week 3 in insulin-treated rats than in saline-treated rats (mean arterial pressure, 137 +/- 3 mm Hg versus 119 +/- 3 mm Hg, p < 0.05; plasma norepinephrine, 0.40 +/- 0.02 ng/ml versus 0.27 +/- 0.01 ng/ml, p < 0.05). Insulin did not influence sodium retention, mean arterial pressure, or plasma norepinephrine in salt-resistant rats. Coadministration of an alpha-blocker (bunazosin, 10 mg/kg per day for 3 weeks) in salt-sensitive rats abolished the insulin-induced elevations in mean arterial pressure and sodium retention. When salt-sensitive rats were fed a low salt diet (0.03% NaCl), insulin did not raise mean arterial pressure. Thus, insulin elevated blood pressure only in the salt-sensitive model. The sympathetic nervous system and sodium retention in the early phase of insulin overload may contribute to elevation of mean arterial pressure in this model. |
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Authors:
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H Tomiyama; T Kushiro; H Abeta; H Kurumatani; H Taguchi; N Kuga; F Saito; F Kobayashi; Y Otsuka; K Kanmatsuse |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hypertension Volume: 20 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1992 Nov |
Date Detail:
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Created Date: 1992-12-01 Completed Date: 1992-12-01 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 596-600 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Surugadai Nihon University Hospital, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure* Drug Resistance / genetics Hyperinsulinism / blood, physiopathology*, urine Insulin / blood Male Natriuresis Norepinephrine / blood Rats Rats, Inbred Strains Sodium Chloride / pharmacology* |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; 51-41-2/Norepinephrine; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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