Document Detail

Blood pressure response to central and/or peripheral inhibition of phenylethanolamine N-methyltransferase in normotensive and hypertensive rats.
MedLine Citation:
PMID:  7249286     Owner:  NLM     Status:  MEDLINE    
We studied the effects on blood pressure and heart rate of two different phenylethanolamine N-methyltransferase (PNMT) inhibitors in normotensive, in two-kidney renal hypertensive, and in deoxycorticosterone-salt (DOC-salt) hypertensive rats. One compound (SK&F 64139) blocks the conversion of norepinephrine to epinephrine in both the central and the peripheral nervous system, whereas the other (SK&F 29661) does not cross the blood-brain barrier and therefore is active mostly in the adrenal glands. In the rats given SK&F 29661, practically no acute blood pressure changes were in the adrenal glands. In the rats given SK&F 64139 induced only a minor blood pressure and heart rate response in normotensive and two-kidney renal hypertensive rats. However, in DOC-salt hypertensive rats, it reduced arterial pressure to approximately normal levels and concomitantly slowed pulse rate. There was a close correlation between the magnitude of the blood pressure response observed in all SK&F 64139-treated animals and the control plasma norepinephrine (4 = -0.795, P less than 0.001) and epinephrine (r = -0.789, P less than 0.001) levels. These results suggest an important role for central epinephrine in regulating the peripheral sympathoadrenomedullary and the baroreceptor reflex activity, particularly when the maintenance of the high blood pressure is not renin-dependent.
J Black; B Waeber; M R Bresnahan; I Gavras; H Gavras
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  49     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-09-25     Completed Date:  1981-09-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  518-24     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects*
Catecholamines / blood
Hypertension / physiopathology*
Isoquinolines / pharmacology
Phenylethanolamine N-Methyltransferase / antagonists & inhibitors*
Sulfonamides / pharmacology
Grant Support
Reg. No./Substance:
0/Catecholamines; 0/Isoquinolines; 0/Sulfonamides; 0/Tetrahydroisoquinolines; 31404-61-2/1,2,3,4-tetrahydroisoquinoline-7-sulfonamide; 57987-77-6/7,8-dichloro-1,2,3,4-tetrahydroisoquinoline; EC N-Methyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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