Document Detail

Blood pressure response to angiotensin converting enzyme inhibitor in essential hypertension: its relation to the renin status and natriuresis during acute sodium loading.
MedLine Citation:
PMID:  7910063     Owner:  NLM     Status:  MEDLINE    
We examined the antihypertensive response to enalapril and its relation to the changes of the renin-angiotensin-aldosterone axis (RAA) in essential hypertensive patients. The responders, whose blood pressure reduced after enalapril administration, had significant elevation of plasma renin activity after enalapril (7.5 +/- 4.0 to 31.9 +/- 10 ng/mL/h, p < 0.05). There was no significant change in the plasma renin activity of the nonresponders (3.0 +/- 1.0 to 5.6 +/- 1.9 ng/mL/h). Natriuretic response to acute salt loading was compared between the two subgroups. The natriuresis on acute salt loading of nonresponders was better than that of the responders (82.9 +/- 13.2 vs 44.5 +/- 5.7 mmol/4h, p < 0.05). These results imply that the RAA and extracellular fluid volume both contribute in different ways to the maintenance of high blood pressure in different subgroups of essential hypertension.
C H Hou; Y M Chen; K D Wu; B S Hsieh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Formosan Medical Association = Taiwan yi zhi     Volume:  92     ISSN:  0929-6646     ISO Abbreviation:  J. Formos. Med. Assoc.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-06-14     Completed Date:  1994-06-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9214933     Medline TA:  J Formos Med Assoc     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  942-7     Citation Subset:  IM    
Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, R.O.C.
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MeSH Terms
Blood Pressure / drug effects*
Enalapril / therapeutic use*
Hypertension / drug therapy,  physiopathology*
Natriuresis / drug effects*
Renin / blood*
Renin-Angiotensin System / drug effects
Sodium / pharmacology*
Reg. No./Substance:
7440-23-5/Sodium; 75847-73-3/Enalapril; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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