| Blood pressure response to an angiotensin II antagonist in thyrotoxic patients with and without high blood pressure. | |
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MedLine Citation:
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PMID: 7408785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An angiotensin II antagonist, [sacrosine1, isoleucine8] angiotensin II, was infused into thyrotoxic patients. Blood pressure was monitored before and during the infusions to investigate whether the renin-angiotensin-aldosterone system was involved in the maintenance of blood pressure in normotensive and hypertensive thyrotoxic patients. Five out of 17 normotensive patients with hyperthyroidism showed more than a 10 mmHg decrease in mean blood pressure in response to the infusion (responders), while the remaining 12 patients showed no substantial change in blood pressure (non-responders). The infusion caused little change in blood pressure in 8 hyperthyroid patients with systolic hypertension. The mean levels of serum thyroxine, triiodothyronine, plasma renin activity and plasma aldosterone concentration in the normotensive responders were significantly higher than the values in the normotensive non-responders. There were no significant differences in these laboratory values between the hypertensive patients and the normotensive non-responders except that serum triiodothyronine levels were significantly higher in the hypertensive patients. The present study indicates that increased activity of the renin-angiotensin-aldosterone system is involved in the maintenance of blood pressure in most normotensive patients with severe hyperthyroidism, while hypertension in patients with hyperthyroidism is not angiotensin II dependent. |
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Authors:
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T Ogihara; T Hata; A Maruyama; H Mikami; M Nakamaru; T Naka; Y Kumahara; K Kuma |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endocrinologia japonica Volume: 27 ISSN: 0013-7219 ISO Abbreviation: Endocrinol. Jpn. Publication Date: 1980 Apr |
Date Detail:
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Created Date: 1980-11-25 Completed Date: 1980-11-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376546 Medline TA: Endocrinol Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 223-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Sarcosine-8-Isoleucine Angiotensin II
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diagnostic use,
pharmacology Adolescent Adult Angiotensin II / antagonists & inhibitors* Blood Pressure / drug effects* Female Humans Hypertension / complications, physiopathology* Hyperthyroidism / complications, physiopathology* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II; 9088-01-1/1-Sarcosine-8-Isoleucine Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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