| Blood pressure, renin-angiotensin-aldosterone axis and cortisol changes during withdrawal from alcohol. | |
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MedLine Citation:
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PMID: 2818749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nineteen patients who had been drinking on the day of admission had significantly raised levels of renin, aldosterone and cortisol and a non-significant increase in angiotensin II. Five patients were hypertensive (systolic blood pressure greater than 160 mmHg or diastolic blood pressure greater than 95 mmHg) at some point during the study and there was a significant tachycardia. Over the first 4 days of abstinence there were falls in all of the measures reaching significance for renin, cortisol, systolic blood pressure and pulse. There were no correlations between blood pressure and any of the hormones measured although there was a significant association between pulse and both aldosterone and cortisol. It is concluded that the activity in the renin-angiotensin axis and hypothalamic-pituitary-adrenal axis is not responsible for alcohol-related changes in blood pressure. |
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Authors:
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A J Mander; A Young; T M MacDonald; B C Williams; C J Waugh; C R Edwards |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Alcohol and alcoholism (Oxford, Oxfordshire) Volume: 24 ISSN: 0735-0414 ISO Abbreviation: Alcohol Alcohol. Publication Date: 1989 |
Date Detail:
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Created Date: 1990-01-05 Completed Date: 1990-01-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8310684 Medline TA: Alcohol Alcohol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 409-14 Citation Subset: IM |
Affiliation:
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University Department of Psychiatry, Royal Edinburgh Hospital, Morningside, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Pressure* Ethanol / adverse effects* Female Humans Hydrocortisone / blood* Male Middle Aged Renin-Angiotensin System* Substance Withdrawal Syndrome / blood, physiopathology* |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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