Document Detail

Blood pressure regulation in ANF-transgenic mice: role of angiotensin and vasopressin.
MedLine Citation:
PMID:  7993880     Owner:  NLM     Status:  MEDLINE    
Transgenic mice overexpressing a transthyretin promoter-ANF structural fusion gene have a life-long reduction in arterial blood pressure compared to nontransgenic littermates. The present study was designed to test the hypothesis that the high plasma level of ANF in the transgenic mice inhibits the renin-angiotensin and/or vasopressin systems, thereby causing the hypotension. Mice were anaesthetized with Inactin and arterial pressure and heart rate were monitored before and during Saralasin infusion and vasopressin V1 receptor blockade. Effectiveness of the blockade was determined by injection of angiotensin and vasopressin before and during Saralasin and V1 receptor antagonist administration. Saralasin was associated with hypotension in both transgenic and nontransgenic mice. The decrease in blood pressure was proportionally greater in the transgenic animals. Vasopressin receptor blockade had little effect on blood pressure in either group. Heart rates were not different between the groups during any maneuver. We conclude that the chronic hypotensive effect of ANF overproduction does not involve the inhibition of either renin-angiotensin or vasopressin systems. The data, however, suggest that the renin-angiotensin system may be stimulated in the ANF-transgenic mice.
B Lichardus; A T Veress; L J Field; H Sonnenberg
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  43     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  1994  
Date Detail:
Created Date:  1995-01-17     Completed Date:  1995-01-17     Revised Date:  2008-04-02    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  CZECH REPUBLIC    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
Department of Physiology, University of Toronto, Canada.
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MeSH Terms
Angiotensin II / antagonists & inhibitors*,  pharmacology
Arginine Vasopressin / pharmacology
Atrial Natriuretic Factor / physiology*
Blood Pressure / drug effects,  physiology*
Heart Rate / drug effects,  physiology
Mice, Transgenic
Receptors, Vasopressin / antagonists & inhibitors
Renin-Angiotensin System / physiology
Saralasin / pharmacology
Vasopressins / antagonists & inhibitors*
Reg. No./Substance:
0/Receptors, Vasopressin; 11000-17-2/Vasopressins; 11128-99-7/Angiotensin II; 113-79-1/Arginine Vasopressin; 34273-10-4/Saralasin; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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