Document Detail


Blood pressure regulation by the kallikrein-kinin system.
MedLine Citation:
PMID:  8742494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The kallikrein-kinin system has a significant role in regulating arterial blood pressure. 2. Reduced formation of the kinin compontents may cause hypertensive diseases. This is because of the fact that this system is responsible for vasodilatation, reduction in total peripheral resistance, natriuresis, diuresis, increasing renal blood flow and releasing various vasodilator agents. 3. Reduced kinin-kallikrein generation in hypertensive subjects may also be associated with genetic and environmental defects. 4. The kallikrein-kinin system when administered to hypertensive patients can lower their raised blood pressure to normotensive levels. 5. The mode of action of angiotensin-converting enzyme inhibitors principally may be dependent on the kinin system protection.
Authors:
J N Sharma; K Uma; A R Noor; A R Rahman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  General pharmacology     Volume:  27     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-10-10     Completed Date:  1996-10-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  55-63     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Universiti Sains Malaysia, Kelantan.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin-Converting Enzyme Inhibitors / pharmacology,  therapeutic use
Base Sequence
Blood Pressure / physiology*
Humans
Hypertension / drug therapy,  physiopathology*
Kallidin / chemistry,  physiology
Kallikrein-Kinin System / physiology*
Kininogens / chemistry,  physiology
Molecular Sequence Data
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Kininogens; 342-10-9/Kallidin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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