| Blood pressure reduction during treatment for alcohol dependence: results from the Combining Medications and Behavioral Interventions for Alcoholism (COMBINE) study. | |
| | |
MedLine Citation:
|
PMID: 18821872 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: Heavy drinking is associated with hypertension. This study evaluated blood pressure changes occurring during treatment for alcohol dependence. PARTICIPANTS: Subjects included 1383 people participating in the Combining Medications and Behavioral Interventions for Alcoholism (COMBINE) study, a large multi-center treatment study for alcohol dependence. MEASUREMENTS: Methods appropriate for repeated-measures data were used to assess the relationship of percentage of drinking days (PDD) to systolic and diastolic blood pressure over a 16-week treatment period. Modification of these associations by demographic and other variables was assessed. FINDINGS: Blood pressure reduction was evident only in people who were above the median blood pressure at baseline. In this group, systolic blood pressure decreased by an average of 12 mmHg and diastolic blood pressure decreased by an average of 8 mmHg. Blood pressure reduction occurred during the first month of treatment. This effect was similar regardless of age, sex, body mass index, reported history of hypertension and use of anti-hypertensive medications. An observed association between blood pressure and PDD in Caucasians was not evident in African Americans due largely to their lower pre-treatment blood pressure. CONCLUSIONS: Reduction in alcohol consumption has a potent anti-hypertensive effect in alcoholics with higher blood pressure. For hypertensive, alcohol-dependent people, treatment for alcoholism should be considered a major component of anti-hypertensive therapy. |
| | |
Authors:
|
Scott H Stewart; Patricia K Latham; Peter M Miller; Patrick Randall; Raymond F Anton |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Addiction (Abingdon, England) Volume: 103 ISSN: 1360-0443 ISO Abbreviation: Addiction Publication Date: 2008 Oct |
Date Detail:
|
Created Date: 2008-09-29 Completed Date: 2008-12-19 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 9304118 Medline TA: Addiction Country: England |
Other Details:
|
Languages: eng Pagination: 1622-8 Citation Subset: IM |
Affiliation:
|
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA. stewarsh@musc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Alcohol Drinking / physiopathology Alcoholism / physiopathology, therapy* Antihypertensive Agents / therapeutic use Blood Pressure / physiology* Body Mass Index Female Humans Hypertension / etiology, prevention & control, therapy* Male Middle Aged Regression Analysis |
| Grant Support | |
ID/Acronym/Agency:
|
K23 AA014188-06/AA/NIAAA NIH HHS; K23AA104188/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Density of alcohol outlets and teenage drinking: living in an alcogenic environment is associated wi...
Next Document: Reducing youth alcohol drinking through a parent-targeted intervention: the Orebro Prevention Progra...