Document Detail

Blood pressure and plasma catecholamines in never-treated parkinsonian patients: effect of a selective D1 agonist (CY 208-243).
MedLine Citation:
PMID:  2320249     Owner:  NLM     Status:  MEDLINE    
We found blood pressure (BP), heart rate (HR), plasma norepinephrine (NE), and epinephrine (E) levels in the lying and the standing positions to be similar in never-treated parkinsonian patients (stages 1 and 2) and age-matched controls. CY 208-243, a new centrally active D1 agonist, significantly decreased BP, HR, and NE (but not E) values in the lying position; it elicited orthostatic hypotension and blunted the rise in NE elicited by standing up. These results indicate that the early stages of Parkinson's disease are not accompanied by major changes in autonomic cardiovascular function and suggest the involvement of central D1-receptors in the control of sympathetic tone.
G Durrieu; J M Senard; O Rascol; M A Tran; X Lataste; A Rascol; J L Montastruc
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  40     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-07     Completed Date:  1990-05-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  707-9     Citation Subset:  AIM; IM    
Laboratoire de Pharmacologie Médicale et Clinique (INSERM U317), Toulouse, France.
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MeSH Terms
Antiparkinson Agents / therapeutic use*
Atropine / diagnostic use
Blood Pressure* / drug effects
Epinephrine / blood*
Heart Rate / drug effects
Indoles / therapeutic use*
Middle Aged
Norepinephrine / blood*,  diagnostic use
Parkinson Disease / blood,  drug therapy,  physiopathology*
Phenanthridines / therapeutic use*
Reference Values
Reg. No./Substance:
0/Antiparkinson Agents; 0/Indoles; 0/Phenanthridines; 100999-26-6/CY 208-243; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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