| Blood pressure and plasma catecholamines in never-treated parkinsonian patients: effect of a selective D1 agonist (CY 208-243). | |
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MedLine Citation:
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PMID: 2320249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We found blood pressure (BP), heart rate (HR), plasma norepinephrine (NE), and epinephrine (E) levels in the lying and the standing positions to be similar in never-treated parkinsonian patients (stages 1 and 2) and age-matched controls. CY 208-243, a new centrally active D1 agonist, significantly decreased BP, HR, and NE (but not E) values in the lying position; it elicited orthostatic hypotension and blunted the rise in NE elicited by standing up. These results indicate that the early stages of Parkinson's disease are not accompanied by major changes in autonomic cardiovascular function and suggest the involvement of central D1-receptors in the control of sympathetic tone. |
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Authors:
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G Durrieu; J M Senard; O Rascol; M A Tran; X Lataste; A Rascol; J L Montastruc |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurology Volume: 40 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-05-07 Completed Date: 1990-05-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 707-9 Citation Subset: AIM; IM |
Affiliation:
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Laboratoire de Pharmacologie Médicale et Clinique (INSERM U317), Toulouse, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antiparkinson Agents
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therapeutic use* Atropine / diagnostic use Blood Pressure* / drug effects Epinephrine / blood* Female Heart Rate / drug effects Humans Indoles / therapeutic use* Male Middle Aged Norepinephrine / blood*, diagnostic use Parkinson Disease / blood, drug therapy, physiopathology* Phenanthridines / therapeutic use* Posture Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Antiparkinson Agents; 0/Indoles; 0/Phenanthridines; 100999-26-6/CY 208-243; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 51-55-8/Atropine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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