Document Detail

Blood pressure and plasma catecholamines in never-treated parkinsonian patients: effect of a selective D1 agonist (CY 208-243).
MedLine Citation:
PMID:  2320249     Owner:  NLM     Status:  MEDLINE    
We found blood pressure (BP), heart rate (HR), plasma norepinephrine (NE), and epinephrine (E) levels in the lying and the standing positions to be similar in never-treated parkinsonian patients (stages 1 and 2) and age-matched controls. CY 208-243, a new centrally active D1 agonist, significantly decreased BP, HR, and NE (but not E) values in the lying position; it elicited orthostatic hypotension and blunted the rise in NE elicited by standing up. These results indicate that the early stages of Parkinson's disease are not accompanied by major changes in autonomic cardiovascular function and suggest the involvement of central D1-receptors in the control of sympathetic tone.
G Durrieu; J M Senard; O Rascol; M A Tran; X Lataste; A Rascol; J L Montastruc
Related Documents :
2268889 - 24-hour profiles of blood pressure and heart rate in cushing's syndrome: relationship b...
18497469 - Blood pressure is the main determinant of the reflection wave in patients with type 2 d...
18258159 - Inelastic compression legging produces gradient compression and significantly higher sk...
16598289 - 'office-hour' ambulatory blood pressure monitoring is sufficient for blood pressure dia...
18332449 - Acute central hemodynamic effects of a volume exchange in peritoneal dialysis.
17531579 - Factors influencing blood pressure response to trandolapril add-on therapy in patients ...
16778329 - Interaction between serotonin 2a receptor and endothelin-1 variants in association with...
2148149 - Age-related antihypertensive and haemodynamic effects of verapamil sr: clinical results...
24955899 - Nutritional status and blood pressure in adolescent students.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  40     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-07     Completed Date:  1990-05-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  707-9     Citation Subset:  AIM; IM    
Laboratoire de Pharmacologie Médicale et Clinique (INSERM U317), Toulouse, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antiparkinson Agents / therapeutic use*
Atropine / diagnostic use
Blood Pressure* / drug effects
Epinephrine / blood*
Heart Rate / drug effects
Indoles / therapeutic use*
Middle Aged
Norepinephrine / blood*,  diagnostic use
Parkinson Disease / blood,  drug therapy,  physiopathology*
Phenanthridines / therapeutic use*
Reference Values
Reg. No./Substance:
0/Antiparkinson Agents; 0/Indoles; 0/Phenanthridines; 100999-26-6/CY 208-243; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Stretch syncope in adolescence.
Next Document:  Vertical ocular motor apraxia.