Document Detail

Blood pressure and plasma catecholamines in acute and prolonged hypoxia: effects of local hypothermia.
MedLine Citation:
PMID:  10601149     Owner:  NLM     Status:  MEDLINE    
This study measured the pressor and plasma catecholamine response to local hypothermia during adaptation to hypobaric hypoxia. Eight healthy men were studied at rest and after 10 and 45 min of local cooling of one hand and forearm as well as after 30 min of rewarming at sea level and again 24 h and 5 days after rapid, passive transport to high altitude (4,559 m). Acute mountain sickness scores ranged from 5 to 16 (maximal attainable score: 20) on the first day but were reduced to 0-8 by the fifth day. Systolic blood pressure, heart rate, and plasma epinephrine increased on day 1 at altitude compared with sea level but declined again on day 5, whereas diastolic and mean blood pressures continued to rise in parallel with plasma norepinephrine. With local cooling, an increased vasoactive response was seen on the fifth day at altitude. Very high pressures were obtained, and the pressure elevation was prolonged. Heart rate increased twice as much on day 5 compared with the other two occasions. Thoracic fluid index increased with cooling on day 5, suggesting an increase in pulmonary vascular resistance. In conclusion, prolonged hypoxia seems to elicit an augmented pressor response to local cooling in the systemic and most likely also the pulmonary circulation.
I L Kanstrup; T D Poulsen; J M Hansen; L J Andersen; M H Bestle; N J Christensen; N V Olsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  87     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-03     Completed Date:  2000-02-03     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2053-8     Citation Subset:  IM; S    
Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, DK-2730 Herlev, Denmark.
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MeSH Terms
Acute Disease
Adaptation, Physiological
Altitude Sickness / blood,  physiopathology*
Blood Pressure*
Chronic Disease
Electric Impedance
Epinephrine / blood*
Heart / physiopathology
Hypothermia, Induced*
Lung / physiopathology
Norepinephrine / blood*
Reference Values
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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