Document Detail


Blood pressure patterns in normal pregnancy, gestational hypertension, and preeclampsia.
MedLine Citation:
PMID:  10948070     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
With the aim to describe the daily pattern of blood pressure during the trimesters of pregnancy in clinically healthy women as well as in pregnant women who developed gestational hypertension or preeclampsia, we analyzed 1494 blood pressure series systematically sampled by ambulatory monitoring for 48 hours every 4 weeks after the first obstetric visit in 124 women with uncomplicated pregnancies, 55 with gestational hypertension, and 23 with a final diagnosis of preeclampsia. The circadian pattern of blood pressure variation for each group and trimester of gestation was established by population multiple-component analysis. A highly statistically significant circadian pattern represented by a linear model that includes components with periods of 24 and 12 hours is demonstrated for systolic and diastolic blood pressure for all groups of pregnant women in all trimesters (P:<0.001 in all cases). The differences in circadian rhythm-adjusted mean between complicated and uncomplicated pregnancies are highly statistically significant in all trimesters (always P:<0.001). There is also a statistically significant difference in circadian amplitude (extent of daily change) of blood pressure between healthy and complicated pregnancies in all trimesters (always P:<0.004). Results further indicate similar circadian characteristics between women who later developed gestational hypertension or preeclampsia in the first trimester of pregnancy. The difference between these 2 groups in circadian mean is statistically significant in the second trimester for systolic (P:=0.022) but not for diastolic blood pressure (P:=0.986). In the third trimester, the difference in circadian mean is highly statistically significant for both variables (P:<0.001). The differences in blood pressure between healthy and complicated pregnancies can be observed as early as in the first trimester of pregnancy. Those highly significant differences are found when both systolic and diastolic blood pressure for women with a later diagnosis of gestational hypertension or preeclampsia are well within the accepted normal physiological range of blood pressure variability. These differing changes in the circadian pattern of blood pressure with advancing gestational age between healthy and complicated pregnancies offer new end points that may lead to an early identification of hypertensive complications in pregnancy as well as to the establishment of prophylactic intervention.
Authors:
R C Hermida; D E Ayala; A Mojón; J R Fernández; I Alonso; I Silva; R Ucieda; M Iglesias
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  36     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-09-14     Completed Date:  2000-09-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  149-58     Citation Subset:  IM    
Affiliation:
Bioengineering and Chronobiology Laboratories, University of Vigo, Campus Universitario, Spain. rhermida@tsc.uvigo.es
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Analysis of Variance
Blood Pressure / physiology*
Blood Pressure Monitoring, Ambulatory
Diastole
Female
Humans
Hypertension / physiopathology*
Pre-Eclampsia / physiopathology*
Pregnancy
Pregnancy Complications, Cardiovascular / physiopathology*
Systole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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