Document Detail

Blood pressure overshoot under pentobarbitone anaesthesia following a single dose of clonidine in rats.
MedLine Citation:
PMID:  7166011     Owner:  NLM     Status:  MEDLINE    
1. Withdrawal of chronic antihypertensive therapy with clonidine is known to produce a blood pressure overshoot. It has been reported that the same may occur after a single dose of clonidine. 2. A single, intramuscular dose of clonidine (0.05 mg/kg) produced an overshoot in blood pressure, on the day following administration, in normotensive rats anaesthetized with sodium pentobarbitone. 3. No rebound elevation of mean arterial pressure or of heart rate occurred in conscious, normotensive, spontaneously hypertensive or renal hypertensive rats following this dose of clonidine, nor did it occur in rats anaesthetized with ether. 4. It is suggested that the overshoot phenomenon in rats under barbiturate anaesthesia may involve an interaction between an effect of clonidine and the barbiturate.
M Parker; R Studer; M Manganel; J Atkinson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  9     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    1982 Nov-Dec
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  685-9     Citation Subset:  IM    
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MeSH Terms
Anesthesia, General*
Blood Pressure / drug effects*
Clonidine / pharmacology*
Hypertension / physiopathology
Hypertension, Renovascular / physiopathology
Pentobarbital / pharmacology*
Rats, Inbred Strains
Reg. No./Substance:
4205-90-7/Clonidine; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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