| Blood pressure measurement in the artery proximal and distal to an intra-arterial embolus during thrombolytic therapy. | |
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MedLine Citation:
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PMID: 21990787 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background and aim When a cerebral embolism occurs, pressure gradients in the arteries between sites proximal and distal to the embolus exert hydromechanical forces that push the embolus distally, and potentially affect successful revascularization during clot removal. We investigated the relationships between blood pressures that occur immediately distal and proximal to the embolus, systemic blood pressure and clinical variables. Methods 36 patients with embolism of the internal carotid artery (13 patients) or the proximal middle cerebral artery (23 patients) were treated using intra-arterial thrombolysis. The mean blood pressure (MBP) at the sites proximal (proximal MBP) and distal (distal MBP) to the embolus was measured with a microcatheter. Simultaneously, the systemic MBP was recorded by cuff measurement. Results Proximal, distal and systemic MBPs (mean±SD) were 95.2±13.2 mm Hg, 35.9±13.5 mm Hg and 98.2±12.2 mm Hg, respectively. The proximal MBP was significantly higher in the patients with systemic MBP≥100 mm Hg than those with systemic MBP<100 mm Hg (p<0.05). The distal MBP showed no difference between the high and normal systemic MBP groups. Conclusions Higher systemic blood pressure produced stronger hydromechanical forces on the clot, forming a proximal-distal blood pressure gradient across the clot. The stronger hydromechanical force could result in higher compaction of the clot, thus making it more difficult to remove. |
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Authors:
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Takatoshi Sorimachi; Kenichi Morita; Yasushi Ito; Yukihiko Fujii |
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Publication Detail:
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Type: Journal Article Date: 2010-12-16 |
Journal Detail:
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Title: Journal of neurointerventional surgery Volume: 3 ISSN: 1759-8486 ISO Abbreviation: J Neurointerv Surg Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101517079 Medline TA: J Neurointerv Surg Country: England |
Other Details:
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Languages: eng Pagination: 43-6 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Brain Research Institute, University of Niigata, Niigata, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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