| Blood pressure means rather than nocturnal dipping pattern are related to complications in Type 2 diabetic patients. | |
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MedLine Citation:
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PMID: 18201207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To determine whether systolic and diastolic blood pressure (BP) means, during ambulatory BP monitoring (ABPM), are more strongly correlated with microvascular complications and echocardiographic structural alterations than night-time/daytime (N/D) BP ratio. METHODS: A cross-sectional study was conducted in 270 Type 2 diabetes mellitus (DM) outpatients who underwent clinical and laboratory investigations, urinary albumin excretion rate (UAER) determination, echocardiography, office and 24-h ABPM (Spacelabs 90207). RESULTS: UAER, after multivariate adjustments, was associated with office BP (systolic: R(2)(a) 0.162, P < 0.001; diastolic: R(2)(a) 0.124, P < 0.001) and ABPM (24-h systolic: R(2)(a) 0.195, P < 0.001; 24-h diastolic: R(2)(a) 0.197, P < 0.001) but not with N/D BP ratios (systolic: R(2)(a) 0.062, P = 0.080; diastolic: R(2)(a) 0.063, P = 0.069). Similar results were observed for echocardiographic parameters. The presence of retinopathy was associated only with night-time BP values [systolic means: odds ratio (OR) 1.13, 95% confidence interval (CI) 1.03-1.24 and diastolic means: OR 1.21, CI 1.04-1.40 and N/D diastolic BP ratio > 0.90, OR 3.21, CI 1.65-6.25]. CONCLUSIONS: UAER and echocardiographic structural alterations had more consistent correlations of a greater magnitude with systolic BP means than with N/D BP ratios. The nocturnal BP values appear to be more relevant for diabetic retinopathy. BP measurement in patients with Type 2 DM should take into account the 24-h period rather than focusing on a specific time span of BP homeostasis. |
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Authors:
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C B Leitão; L H Canani; C K Kramer; M Moehlecke; L C Pinto; E D Ricardo; A F Pinotti; J L Gross |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-14 |
Journal Detail:
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Title: Diabetic medicine : a journal of the British Diabetic Association Volume: 25 ISSN: 1464-5491 ISO Abbreviation: Diabet. Med. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-29 Completed Date: 2008-06-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500858 Medline TA: Diabet Med Country: England |
Other Details:
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Languages: eng Pagination: 308-13 Citation Subset: IM |
Affiliation:
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Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. crisbleitao@yahoo.com.br |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Albuminuria / metabolism* Blood Pressure / physiology* Blood Pressure Monitoring, Ambulatory Circadian Rhythm / physiology Diabetes Mellitus, Type 2 / physiopathology* Diabetic Angiopathies / physiopathology* Diabetic Nephropathies / physiopathology* Diabetic Retinopathy / physiopathology* Female Humans Hypertension / physiopathology Male Middle Aged |
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