Document Detail

Blood pressure lowering and stroke.
MedLine Citation:
PMID:  20136379     Owner:  NLM     Status:  MEDLINE    
Hypertension is the most prevalent of the modifiable risk factors for stroke. The benefits of blood pressure (BP) lowering on primary and secondary prevention of stroke are undeniable. Despite this, BP control in hypertensive individuals and patients with prior cerebrovascular events is suboptimal. Noncompliance, inappropriate antihypertensive usage and under-utilization of medications contribute significantly to inadequate BP control. Recently, elegantly designed studies that assessed the preventive role of BP lowering in patients with cerebrovascular disease have helped clarify management issues in terms of BP targets and effective antihypertensive regimens. Current evidence suggests that BP targets for primary and secondary prevention are suboptimal and need reassessment. The effect of BP modulation in acute stroke is still not completely understood. Although the thresholds for BP treatment in acute stroke have been recommended, BP targets are as yet ill-defined. The available evidence supports early lowering of blood pressure following stroke. This review discusses the impact of blood pressure on stroke incidence and outcomes, outlines the recommendations for blood pressure lowering in stroke and delineates questions that still need to be addressed.
Monica Saini; Ashfaq Shuaib
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of neurotherapeutics     Volume:  10     ISSN:  1744-8360     ISO Abbreviation:  Expert Rev Neurother     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-08     Completed Date:  2010-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101129944     Medline TA:  Expert Rev Neurother     Country:  England    
Other Details:
Languages:  eng     Pagination:  225-41     Citation Subset:  IM    
Division of Neurology, Department of Medicine, University of Alberta, AB, Canada.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects,  physiology*
Clinical Trials as Topic
Hypertension / complications*,  drug therapy
Stroke / drug therapy,  etiology*,  prevention & control*
Reg. No./Substance:
0/Antihypertensive Agents

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