| Blood pressure lowering for the prevention of cognitive decline in patients with cerebrovascular disease. PROGRESS Management Committee. Perindopril Protection Against Recurrent Stroke Study. | |
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MedLine Citation:
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PMID: 9247759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebrovascular disease and high blood pressure both appear to increase the risk of vascular dementia. PROGRESS aims to investigate whether blood pressure lowering with an angiotensin coverting enzyme inhibitor-based regimen will reduce the risk of cognitive impairment in patients with a history of stroke or transient ischaemic attack. A total of at least 6000 patients will be randomised to receive perindopril (+/- indapamide) or matching placebo(s), with treatment and follow-up scheduled to continue for at least 4 years. Substudies will investigate the effects of treatment on cognitive decline in subgroups defined by apo-E genotype and on white matter lesions assessed by magnetic resonance imaging. Final results from the study should be available in 2001. |
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Authors:
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G Whitlock; S MacMahon; C Anderson; B Neal; A Rodgers; J Chalmers |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: 19 ISSN: 1064-1963 ISO Abbreviation: Clin. Exp. Hypertens. Publication Date: 1997 Jul-Aug |
Date Detail:
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Created Date: 1997-09-29 Completed Date: 1997-09-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 843-55 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Auckland, New Zealand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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pharmacology* Antihypertensive Agents / pharmacology* Blood Pressure / drug effects* Cerebrovascular Disorders / drug therapy*, physiopathology, psychology Clinical Protocols Dementia, Vascular / physiopathology, prevention & control* Diuretics / pharmacology Female Humans Indapamide / pharmacology Indoles / pharmacology* Ischemic Attack, Transient / drug therapy, physiopathology, psychology Male Middle Aged Perindopril |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Diuretics; 0/Indoles; 26807-65-8/Indapamide; 82834-16-0/Perindopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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