| Blood pressure-lowering effect and duration of action of bedtime administration of doxazosin determined by home blood pressure measurement. | |
| | |
MedLine Citation:
|
PMID: 20662733 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects and duration of action of bedtime administration of doxazosin 2 mg for 4 weeks on uncontrolled morning home hypertension were investigated. Morning home blood pressure (HBP) was significantly lowered by bedtime administration of doxazosin. Doxazosin significantly lowered evening HBP only in the subgroup of patients with an uncontrolled evening HBP. The evening (E)/morning (M) ratio was greater in patients with an uncontrolled evening HBP than in those with a controlled evening HBP. The results suggest that bedtime administration of doxazosin effectively suppresses morning HBP in uncontrolled morning hypertensives and lowers evening HBP in uncontrolled evening hypertensives. |
| | |
Authors:
|
Kenta Gonokami; Taku Obara; Mitsuru Kobayashi; Sakiko Katada; Azusa Hara; Hirohito Metoki; Kei Asayama; Masahiro Kikuya; Takayoshi Ohkubo; Yutaka Imai |
Related Documents
:
|
9771513 - Ambulatory blood pressure monitoring for hypertension in general practice. 18622223 - European society of hypertension guidelines for blood pressure monitoring at home: a su... 9719053 - Intrarenal nitric oxide activity and pressure natriuresis in anesthetized dogs. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: 32 ISSN: 1525-6006 ISO Abbreviation: Clin. Exp. Hypertens. Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-07-28 Completed Date: 2010-11-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: England |
Other Details:
|
Languages: eng Pagination: 311-7 Citation Subset: IM |
Affiliation:
|
Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angiotensin II Type 1 Receptor Blockers / therapeutic use Angiotensin-Converting Enzyme Inhibitors / therapeutic use Antihypertensive Agents / administration & dosage*, pharmacology*, therapeutic use Blood Pressure / drug effects*, physiology Blood Pressure Monitoring, Ambulatory* Calcium Channel Blockers / therapeutic use Circadian Rhythm / physiology Diuretics / therapeutic use Dose-Response Relationship, Drug Doxazosin / administration & dosage*, pharmacology*, therapeutic use Drug Administration Schedule Drug Therapy, Combination Female Humans Hypertension / drug therapy, physiopathology* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Diuretics; 74191-85-8/Doxazosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Correlation between the levels of circulating adhesion molecules and atherosclerosis in hypertensive...
Next Document: Macrophage-mediated proteolytic remodeling of the extracellular matrix in atherosclerosis results in...