Document Detail


Blood pressure lowering, cardiovascular inhibitory and bronchodilatory actions of Achillea millefolium.
MedLine Citation:
PMID:  20857434     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Achillea millefolium Linn. (Asteraceae) is used in folk medicine for the treatment of overactive cardiovascular and respiratory ailments. This study describes its hypotensive, cardio-depressant, vasodilatory and bronchodilatory activities. The crude extract of Achillea millefolium (Am.Cr) caused a dose-dependent (1-100 mg/kg) fall in arterial blood pressure of rats under anaesthesia. In spontaneously beating guinea-pig atrial tissues, Am.Cr exhibited negative inotropic and chronotropic effects. In isolated rabbit aortic rings, Am.Cr at 0.3-10 mg/mL relaxed phenylephrine (PE, 1 µm) and high K(+) (80 mm)-induced contractions, as well as suppressed the PE (1 µm) control peaks obtained in Ca(++) -free medium, like that caused by verapamil. The vasodilator effect of Am.Cr was partially blocked by N(ω) -nitro-l-arginine methyl ester in endothelium intact preparations. In guinea-pig tracheal strips, Am.Cr inhibited carbachol (CCh, 1 µm) and K(+) -induced contractions. These results indicate that Achillea millefolium exhibits hypotensive, cardiovascular inhibitory and bronchodilatory effects, thus explaining its medicinal use in hyperactive cardiovascular and airway disorders, such as hypertension and asthma. Copyright © 2010 John Wiley & Sons, Ltd.
Authors:
Arif-Ullah Khan; Anwarul Hasan Gilani
Related Documents :
8897924 - Nitric oxide synthase inhibition reduces venous return in porcine endotoxemia.
7475134 - Simultaneous manipulation of the nitric oxide and prostanoid pathways reduces myocardia...
12890294 - Description and evaluation of a delivery system for aerosolized prostacyclin.
7821344 - Influence of n omega-nitro-l-arginine methyl ester, ly83583, glybenclamide and l158809 ...
23849684 - Collision and phonation threshold pressures before and after loud, prolonged vocalizati...
18037774 - The effect of combination therapy with an l/n-type ca(2+) channel blocker, cilnidipine,...
Publication Detail:
Type:  Journal Article     Date:  2010-09-20
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  25     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  577-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 John Wiley & Sons, Ltd.
Affiliation:
Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi-74800, Pakistan; Institute of Pharmaceutical Sciences, Kohat University of Science and Technology, Kohat-26000, Pakistan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The in vivo pig-a gene mutation assay, a potential tool for regulatory safety assessment.
Next Document:  The 40th anniversary of the Environmental Mutagen Society.