Document Detail


Blood pressure and lifespan following brief ACE inhibitor treatment in young spontaneously hypertensive rats.
MedLine Citation:
PMID:  8039264     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Brief treatment with angiotensin-converting enzyme (ACE) inhibitors in young spontaneously hypertensive rats (SHR) causes a reduction in blood pressure that persists into maturity. The lifetime effects of such treatment have not been studied. 2. Nineteen male SHR were treated with either water (n = 9) or perindopril (3 mg/kg per day) (n = 10) by daily gavage between 6 and 10 weeks of age and systolic blood pressure and bodyweight were measured each month until all animals died in old age. 3. Following treatment the systolic blood pressure of SHR treated with perindopril remained consistently lower than control SHR until about 82 weeks of age. After this age the blood pressure of control SHR fell spontaneously so that smaller differences were observed between the two groups in the last 4 months of the study. 4. Rats that received perindopril lived on average 1 month longer than control rats, but this difference was not statistically significant. 5. Thus, brief ACE inhibition in early life in SHR ameliorated the hypertension throughout life.
Authors:
S B Harrap; C Mirakian; S R Datodi; A F Lever
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  21     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-08-22     Completed Date:  1994-08-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  125-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Animals
Blood Pressure / drug effects*
Body Weight / drug effects
Indoles / pharmacology
Life Expectancy
Male
Perindopril
Rats
Rats, Inbred SHR
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Indoles; 82834-16-0/Perindopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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