| Blood pressure levels, left ventricular mass and function are correlated with left atrial volume in mild to moderate hypertensive patients. | |
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MedLine Citation:
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PMID: 19262581 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arterial hypertension is associated with an increased risk of atrial fibrillation (AF), and leads to a pronounced increase in morbidity and mortality. Left atrial volume (LAV) is an important prognostic marker in the older populations. The aim of our study was to identify the clinical and echocardiographic determinants of LAV in middle-aged (<70 years old) essential hypertensive patients.We evaluated cardiac structure and function in 458 patients, 394 treated and untreated mild to moderate essential hypertensives patients (mean+/-s.d. age 48.4+/-11.1 years) with no associated clinical condition and 64 normotensive control participants (age 45.7+/-12.8 years; P=0.12). A multivariate analysis was performed to calculate the relative weight of each of the variables considered able to predict LAV. The LAV index (LAVi) was significantly increased in the essential hypertensive group vs the control group and was significantly dependent on blood pressure levels (SBP and DBP, P<0.05 for both) and body mass index (BMI) (P<0.0001). Considering the left ventricular (LV) variables, the LV mass index (LVMI) (R(2)=0.19, P<0.001) and LAV were increased in essential hypertensive patients with left ventricular hypertrophy (LVH), and patients with enlarged LAV showed lower systolic and diastolic function and an increased LVMI. The LAVi is dependent on blood pressure levels and anthropometric variables (age and BMI). Further structural (LVMI) and functional (systolic and diastolic) variables are related to the LAVi; LVMI is the most important variable associated with LAV in mild to moderate essential hypertensive adult patients. These findings highlight the importance of left atrium evaluation in adult, relatively young, essential hypertensive patients. |
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Authors:
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A Milan; M A Caserta; A Dematteis; D Naso; A Pertusio; C Magnino; E Puglisi; F Rabbia; N G Pandian; P Mulatero; F Veglio |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-05 |
Journal Detail:
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Title: Journal of human hypertension Volume: 23 ISSN: 1476-5527 ISO Abbreviation: J Hum Hypertens Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-15 Completed Date: 2009-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 743-50 Citation Subset: IM |
Affiliation:
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Hypertension Unit, Department of Medicine and Experimental Oncology, Division of Internal Medicine, University of Torino, Torino, Italy. alby.milan@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Antihypertensive Agents / therapeutic use Atrial Fibrillation / etiology*, physiopathology, ultrasonography Blood Pressure* Body Mass Index Case-Control Studies Echocardiography, Doppler Heart Atria / ultrasonography Heart Ventricles / physiopathology*, ultrasonography Humans Hypertension / complications, drug therapy, physiopathology*, ultrasonography Hypertrophy, Left Ventricular / etiology, physiopathology Linear Models Middle Aged Predictive Value of Tests Risk Assessment Risk Factors Severity of Illness Index Ventricular Function, Left* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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