Document Detail

Blood pressure levels in childhood: probing the relative importance of birth weight and current size.
MedLine Citation:
PMID:  18830709     Owner:  NLM     Status:  MEDLINE    
Several studies have reported data supporting the idea that an impaired intrauterine environment that deprives the fetus of optimal nutrient delivery results in the predisposition of the fetus to experience cardiovascular and metabolic dysfunction in later life. However, contradictory data still exist. Our purpose was to investigate the effects of both birth weight and weight gain on the risk for high blood pressure levels in 6- to 10-year-old children. This cross-sectional study included 739 children divided into quartiles of birth weight. The mean values of both systolic and diastolic pressure were significantly different between quartiles of birth weight, with increasing blood pressure values as the birth weight decreased (P<0.001). Covariance analysis adjusting for gender, prematurity, and body mass index (BMI) showed that both systolic and diastolic pressure remained greater in the lowest than in the highest birth weight quartile. Separating those with low and normal birth weight demonstrated that the risk of childhood hypertension was significantly higher among children with low birth weight and current obesity (odds ratio [OR]: 5.0, confidence interval [CI]: 3.3 to 16.1; P=0.023). The inverse association between birth weight and blood pressure levels appears to be programmed during fetal life, while weight gain during childhood adds to this risk.
Maria Wany L Strufaldi; Edina M K Silva; Maria C P Franco; Rosana F Puccini
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Publication Detail:
Type:  Journal Article     Date:  2008-10-02
Journal Detail:
Title:  European journal of pediatrics     Volume:  168     ISSN:  1432-1076     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-03-18     Completed Date:  2009-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  619-24     Citation Subset:  IM    
Department of Pediatrics, School of Medicine, Federal University of São Paulo, R. Botucatu, 598, São Paulo, SP 04023-062, Brazil.
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MeSH Terms
Birth Weight*
Blood Pressure / physiology*
Body Mass Index
Body Size*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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