Document Detail

Blood pressure in obese adolescents: effect of weight loss.
MedLine Citation:
PMID:  3288957     Owner:  NLM     Status:  MEDLINE    
The BP distribution of a group of 72 obese adolescents was determined both before and after weight loss. Weight loss was produced by a program of caloric restriction and behavior change alone (n = 26) or with a combination of caloric restriction, behavior change, and exercise (n = 25). It was demonstrated that obese adolescents have a BP distribution that is skewed 1 SD to the right of normal (P less than .01), and that with weight loss this distribution was no longer different from that of the general population. It was also shown that a weight loss program that incorporates exercise and caloric restriction produces the most desirable effect on BP reduction (ie, greatest decrease in resting systolic BP and greatest decrease in exercise diastolic and mean BP). Finally, it was demonstrated that obese adolescents have structural changes present in the forearm resistance vessels and that these structural changes are reversed to the greatest extent in the weight loss program that includes exercise.
A P Rocchini; V Katch; J Anderson; J Hinderliter; D Becque; M Martin; C Marks
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  82     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-07-18     Completed Date:  1988-07-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  16-23     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Michigan, Ann Arbor.
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MeSH Terms
Adolescent Behavior
Analysis of Variance
Blood Pressure*
Body Composition
Body Weight*
Clinical Trials as Topic
Diet, Reducing
Energy Intake
Forearm / blood supply
Heart Rate*
Obesity / diet therapy,  physiopathology*,  therapy
Oxygen Consumption
Physical Exertion
Random Allocation
Regression Analysis
Vascular Resistance
Grant Support
2R01-HL-35743/HL/NHLBI NIH HHS; M01-RP00042-21//PHS HHS; R01-AM309-89/AM/NIADDK NIH HHS

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