Document Detail

Blood pressure in middle-aged women: are androgens involved? A population-based study of Swedish women: the Women's Health in the Lund Area study.
MedLine Citation:
PMID:  17885546     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the prevalence of hypertension and use of antihypertensive drug therapy in relation to menopausal status and to delineate perceived associations between androgens and blood pressure in perimenopausal women. METHODS: A population-based sample of women aged 50-59 (n = 6893). Women were divided into three groups according to their hormonal status: premenopausal, postmenopausal without hormone therapy, and postmenopausal with hormone therapy. RESULT: In the premenopausal, postmenopausal without hormone therapy, and postmenopausal with hormone therapy groups, the prevalence of high blood pressure (>/= 140 mmHg systolic or >/= 90 mmHg diastolic) was 43.9, 49.9 and 45.8%, respectively. In women with normal blood pressure, adjusting for age, body mass index and smoking, there were negative associations between serum testosterone and systolic blood pressure in the total sample (P < 0.01) and the postmenopausal without hormone therapy group (P < 0.05). In women using antihypertensive drug therapy with a blood pressure of at least 140/90 mmHg, positive associations were found between serum testosterone and systolic blood pressure in the total series (P < 0.05) and in the postmenopausal without hormone therapy group (P < 0.05). CONCLUSION: Abnormal blood pressure is common in middle-aged women regardless of hormonal status. Our findings suggest that testosterone could have a dual influence on blood pressure in perimenopausal women.
Ali Khatibi; Carl-David Agardh; Per Nyberg; Jonas Lidfeldt; Göran Samsioe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  25     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-21     Completed Date:  2008-01-02     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  2044-50     Citation Subset:  IM    
Department of Gynaecology and Obstetrics, Sweden.
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MeSH Terms
Androgens / blood,  physiology*
Androstenedione / blood,  physiology
Antihypertensive Agents / therapeutic use
Blood Pressure / physiology*
Estrogen Replacement Therapy
Hypertension / drug therapy,  epidemiology,  physiopathology
Middle Aged
Postmenopause / physiology
Premenopause / physiology
Sweden / epidemiology
Testosterone / blood,  physiology
Reg. No./Substance:
0/Androgens; 0/Antihypertensive Agents; 58-22-0/Testosterone; 63-05-8/Androstenedione

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