| Blood pressure in a hypertensive mouse model of SLE is not salt-sensitive. | |
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MedLine Citation:
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PMID: 21917908 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Systemic lupus erythematosus (SLE) is a risk factor for hypertension. Previously we demonstrated that an established mouse model of SLE (female NZBWF1 mice) develops hypertension with renal inflammation and oxidative stress, both characteristics known as contributing mechanisms to the development of salt-sensitive hypertension. Based on this, we hypothesized blood pressure in SLE mice would be salt-sensitive. Thirty-week old female SLE and control mice (NZW/LacJ) were fed 8% high salt (HS) diet or normal diet (0.4% salt) for 4 weeks. Plasma levels of double stranded DNA (dsDNA) autoantibodies, a marker of SLE disease activity, were increased in SLE mice compared to controls (472 ± 148 vs. 57 ± 17 U/mL x 1000, p<0.001). HS did not alter dsDNA autoantibody levels in SLE or control mice. Mean arterial pressure was increased in SLE mice compared to controls (132 ± 3 vs. 118 ± 2 mmHg, p<0.001) and was not significantly altered by the HS diet in either group. Similarly, albuminuria was higher in SLE mice compared to controls (10.7 ± 9.0 vs. 0.3 ± 0.1 mg/day) but was not significantly increased in SLE or control mice fed a HS diet. In summary, blood pressure during SLE is not salt-sensitive and the HS diet did not adversely affect SLE disease activity or significantly augment albuminuria. These data suggest that renal inflammation and oxidative stress, characteristics common to both SLE and models of salt-sensitive hypertension, may have diverging mechanistic roles in the development of hypertension. |
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Authors:
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Keisa W Mathis; Marcia R Venegas-Pont; C Warren Masterson; Katie L Wasson; Michael J Ryan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-14 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: - ISSN: 1522-1490 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Mississippi Medical Center. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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