| Blood pressure and hypertension in relation to levels of serum polychlorinated biphenyls in residents of Anniston, Alabama. | |
| | |
MedLine Citation:
|
PMID: 20644494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine risk factors for elevated blood pressure and hypertension in residents of Anniston, Alabama who live near a plant that manufactured polychlorinated biphenyls (PCBs). METHODS: A total of 758 Anniston residents had multiple measurements of blood pressure, provided information on demographic factors, medications, smoking, and exercise, and provided blood samples for determination of PCBs and total serum lipid. RESULTS: Rates of hypertension increased significantly (P < 0.05) with age and concentration of serum PCBs and were higher in African-Americans (n = 351) than in whites (n = 407). Hypertension also increased with BMI, but was not related to total serum lipid, sex, smoking, or exercise. Among 394 persons not on antihypertensive medication, linear regression analysis demonstrated a significant positive relation between serum PCB level and both systolic and diastolic blood pressure. After adjustment for potentially confounding variables, logistic regression gave odds ratios for the highest to lowest tertiles of total serum PCBs that exceeded 3.5 for both systolic and diastolic hypertension. When analyzed by quintiles of PCBs, the highest odds ratio was in the third quintile, suggesting a low dose effect. CONCLUSION: In individuals not on antihypertensive medication, serum PCB levels were significantly associated with prevalence of hypertension. Significant positive associations were also observed between PCB concentrations and systolic and diastolic blood pressure even in normotensive ranges. The strength of the relationships between PCB exposure and both hypertension and blood pressure suggests that PCB exposure may be an important contributing factor in regulation of blood pressure. |
| | |
Authors:
|
Alexey Goncharov; Michael Bloom; Marian Pavuk; Irina Birman; David O Carpenter |
Related Documents
:
|
2612534 - Effect of pindolol on changes in serum lipids induced by hydrochlorthiazide. 11910674 - High resolution ultrasound assessment of the carotid artery: its relevance in postmenop... 20361714 - Blood pressure lowering, fibrinolysis enhancing and antioxidant activities of cardamom ... 18662594 - Association between serum lipids, blood pressure, and simple anthropometric measures in... 6301124 - Patterns of interaction of effects of light metabolically inert gases with those of hyd... 1785234 - Effects of pleural fluid and positive end-expiratory pressure on the measurement of ext... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of hypertension Volume: 28 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-16 Completed Date: 2011-01-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
|
Languages: eng Pagination: 2053-60 Citation Subset: IM |
Affiliation:
|
Department of Environmental Health Sciences, School of Public Health, University at Albany, Rensselaer, New York 12144, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult African Americans Aged Aged, 80 and over Alabama / epidemiology Blood Pressure / physiology* Cross-Sectional Studies Environmental Pollutants / adverse effects European Continental Ancestry Group Female Humans Hypertension / chemically induced, epidemiology*, physiopathology* Logistic Models Male Middle Aged Polychlorinated Biphenyls / adverse effects, blood* Prevalence Risk Factors Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
5U50TS473215/TS/ATSDR HHS |
| Chemical | |
Reg. No./Substance:
|
0/Environmental Pollutants; 0/Polychlorinated Biphenyls |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fatal burn injury related to liquefied petroleum gas.
Next Document: Modest reductions in dose intensity and drug-induced neutropenia have no major impact on survival of...