Document Detail

Blood pressure, hypertension, and age as risk factors for poor cognitive performance.
MedLine Citation:
PMID:  8595804     Owner:  NLM     Status:  MEDLINE    
The relationships of three blood pressure variables (systolic and diastolic pressures and chronicity of hypertension) and age to cognitive performance on the Kaplan-Albert Neuropsychological Test Battery were explored in a sample of 1,695 stroke-free participants of the Framingham Heart Study. Multiple blood pressure measurements were obtained over four or five exams extending over 8-10 years. Neuropsychological testing was conducted 12-14 years after the final blood pressure measurement. Data were subject to multiple binary logistic regression analyses, and odds ratios were calculated for performance in the lower 50th and 25th percentiles for 10-mmHg increases in diastolic blood pressure, 20-mmHg increases in systolic blood pressure, proportion of exams (out of four or five) in which participants were diagnosed as hypertensive, and 10-year increases in age. Blood pressures and chronicity of hypertension were inversely associated with performance on visual and verbal memory tests of the Kaplan-Albert battery. Age was inversely associated with performance on all tests in the battery. Generally, the odds of performing poorly were higher for age than for the blood pressure variables. The epidemiological significance of these findings is discussed in terms of implications for public health and management of hypertension.
P K Elias; R B D'Agostino; M F Elias; P A Wolf
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental aging research     Volume:  21     ISSN:  0361-073X     ISO Abbreviation:  Exp Aging Res     Publication Date:    1995 Oct-Dec
Date Detail:
Created Date:  1996-04-16     Completed Date:  1996-04-16     Revised Date:  2008-02-25    
Medline Journal Info:
Nlm Unique ID:  7603335     Medline TA:  Exp Aging Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  393-417     Citation Subset:  IM    
Department of Mathematics, Boston University, MA 02215, USA.
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MeSH Terms
Aged, 80 and over
Aging / physiology*,  psychology*
Blood Pressure*
Cognition Disorders / epidemiology*
Hypertension / physiopathology*,  psychology*
Middle Aged
Neuropsychological Tests
Odds Ratio
Regression Analysis
Risk Factors
Grant Support
2-R01-AG08122-06/AG/NIA NIH HHS; 5-R37-AG03055-13/AG/NIA NIH HHS; K01-AG0646-01/AG/NIA NIH HHS

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