Document Detail

Blood pressure and heart rate effect of a vasopressin antagonist in conscious normotensive rats pretreated with exogenous vasopressin.
MedLine Citation:
PMID:  6688586     Owner:  NLM     Status:  MEDLINE    
The blood pressure and heart rate effects of the specific pressor antagonist of vasopressin d(CH2)5Tyr(Me)AVP, 5 micrograms i.v. was evaluated in conscious normotensive rats. Our results suggest that a baroreceptor reflex mediated decrease in sympathetic nerve activity, as reflected by a slowing in heart rate, returns blood pressure to baseline levels shortly after injections of exogenous vasopressin. This has to be taken into account when interpreting the hemodynamic response to vasopressin antagonists in rats pretreated with this vasopressive hormone.
B Waeber; J Nussberger; H R Brunner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  91     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  135-7     Citation Subset:  IM    
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MeSH Terms
Arginine Vasopressin / analogs & derivatives*,  pharmacology
Blood Pressure / drug effects*
Dose-Response Relationship, Drug
Heart Rate / drug effects*
Lypressin / pharmacology
Rats, Inbred Strains
Time Factors
Vasopressins / antagonists & inhibitors*
Reg. No./Substance:
11000-17-2/Vasopressins; 113-79-1/Arginine Vasopressin; 50-57-7/Lypressin; 73168-24-8/vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine-

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