Document Detail

Blood pressure elevation caused by inhibition of brain glutathione reductase.
MedLine Citation:
PMID:  2698933     Owner:  NLM     Status:  MEDLINE    
The effect of brain glutathione reductase activity on blood pressure regulation was investigated. The intravenous administration of the glutathione reductase inhibitor, nitrofurantoin (0.1-0.3 mg/rat), to seven normotensive Wistar rats caused dose-dependent rises in blood pressure and the heart rate (delta mean blood pressure 17 +/- 1 mmHg; delta heart rate 89 +/- 7 beats/min for 0.3 mg). Rats treated with 0.3 mg nitrofurantoin showed a 50% decrease in glutathione reductase activity with a twofold increase in the ratio of glutathione disulphide to reduced glutathione in the hypothalamus and brainstem, and a 1.5-fold increase in plasma noradrenaline and plasma renin activity compared with controls. These nitrofurantoin-induced effects were totally abolished by pretreatment with a sympathetic ganglion blocker (4 mg pentolinium tartrate, administered subcutaneously) except for the increased ratio of glutathione disulphide to reduced glutathione and the decreased glutathione reductase activity in the brain. These results suggest that the blood pressure elevation caused by inhibition of brain glutathione reductase activity occurs through activation of the sympathetic nervous system and the renin-angiotensin system.
E Murakami; J Ishii; S Muneta; K Hiwada; T Kokubu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  7     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-05-11     Completed Date:  1990-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S24-5     Citation Subset:  IM    
2nd Department of Internal Medicine, Ehime University School of Medicine, Japan.
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MeSH Terms
Blood Pressure / drug effects*
Brain / drug effects,  enzymology*
Glutathione Reductase / antagonists & inhibitors*
Nitrofurantoin / pharmacology
Norepinephrine / blood
Pentolinium Tartrate / pharmacology
Rats, Inbred Strains
Renin / blood
Reg. No./Substance:
51-41-2/Norepinephrine; 52-62-0/Pentolinium Tartrate; 67-20-9/Nitrofurantoin; EC Reductase; EC

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