Document Detail


Blood pressure effects of naproxcinod in hypertensive patients.
MedLine Citation:
PMID:  21545399     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The blood pressure (BP) effects of naproxcinod and naproxen were assessed in an 8-week, double-blind, crossover study in 131 hypertensive patients aged 50 to 74 years. Patients received naproxcinod 750 mg twice daily or naproxen 500 mg twice daily, then the alternate treatment, each for 14 days, with placebo run-in/washout before each active treatment period and 24-hour ambulatory BP monitoring conducted before and after each active treatment period. Mean change from baseline in average 24-hour systolic BP (SBP) after 2 weeks of treatment numerically favored naproxcinod 750 mg twice daily (least-squares [LS] mean for naproxcinod minus naproxen: -1.6 mm Hg; P=.12). Post hoc analyses showed statistically significant SBP differences favoring naproxcinod for the 8 elapsed hours (LS mean: -4.4 mm Hg; P<.0001) and the 24 hours following morning dosing (LS mean: -2.4 mm Hg; P=.006). Naproxcinod may be a beneficial alternative for patients with osteoarthritis requiring nonsteroidal anti-inflammatory drugs. J Clin Hypertens (Greenwich). 2011;13:376-384. ©2011 Wiley Periodicals, Inc.
Authors:
Raymond Townsend; Neville Bittar; Jeffrey Rosen; William Smith; Andrea Ramsay; Steven G Chrysant; Robert Weiss; Aldina Pivodic; Brigitte Duquesroix; Jacques Djian
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Publication Detail:
Type:  Journal Article     Date:  2011-01-25
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  13     ISSN:  1751-7176     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  376-84     Citation Subset:  IM    
Copyright Information:
© 2011 Wiley Periodicals, Inc.
Affiliation:
From the University of Pennsylvania, Philadelphia, PA;the Gemini Scientific, LLC, Madison, WI;the Clinical Research of South Florida, Coral Gables, FL;the New Orleans Center for Clinical Research, University of Tennessee Medical Center, Knoxville, TN;the University Clinical Research, Inc, Pembroke Pines, FL;the Oklahoma Cardiovascular and Hypertension Center, Oklahoma City, OK;the Maine Research Associates, Auburn, ME;the NicOx S.A., Sophia-Antipolis, France.
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