Document Detail

Blood pressure effects of acute intravenous renin or oral angiotensin converting enzyme inhibition in essential hypertension.
MedLine Citation:
PMID:  8064166     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the participation of the renin-angiotensin system in the blood pressure regulation of essential hypertensive patients through acute specific renin inhibition. DESIGN AND METHODS: Fifty-three consecutive untreated hypertensive patients (mean +/- SD age 55 +/- 10 years, 42 male) were investigated on their usual sodium diet in a 3-h protocol. The first 11 patients did not receive any drug, the following 20 patients ingested a single oral dose of captopril (1 mg/kg) and the last 22 patients received a renin inhibitor infusion (remikiren; 1 mg/kg over 60 min). RESULTS: The maximum diastolic blood pressure fall was comparable in the two treated groups. Diastolic blood pressure changes analysed as area under the curve were similar for both drugs (overall F1,40 = 1.26, P = 0.27). Even though the baseline renin levels were within the narrow range 5-80 pg/ml, the diastolic blood pressure fall analysed as area under the curve from time 32 min to time 60 min was significantly correlated with the baseline active renin level in both groups (remikiren r = 0.44, P < 0.05; captopril r = 0.47, P < 0.05). The plasma active renin levels were significantly increased at 30, 90 and 120 min in both groups, and the maximum active renin levels were significantly correlated with the baseline active renin level (remikiren r = 0.62, P < 0.01; captopril r = 0.66, P < 0.01). The plasma prorenin levels did not change. CONCLUSIONS: This study suggests that acute renin inhibition and acute angiotensin converting enzyme inhibition similarly decrease the blood pressure and increase the plasma active renin levels. Acute blockade of the renin-angiotensin system at its initial step by a renin inhibitor can therefore be used to investigate the renin dependence of the blood pressure in essential hypertension.
M Azizi; T T Guyene; G Chatellier; J Ménard
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  12     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-09-20     Completed Date:  1994-09-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  419-27     Citation Subset:  IM    
Broussais Hospital Clinical Investigation Centre, Assistance Publique des Hôpitaux de Paris, France.
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MeSH Terms
Administration, Oral
Angiotensin I / biosynthesis
Angiotensin II / blood
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Blood Pressure / drug effects*
Captopril / pharmacology
Hemodynamics / drug effects
Hypertension / blood,  physiopathology*
Imidazoles / pharmacology
Injections, Intravenous
Middle Aged
Renin / antagonists & inhibitors,  blood,  pharmacology*
Time Factors
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Imidazoles; 11128-99-7/Angiotensin II; 135669-48-6/remikiren; 62571-86-2/Captopril; 9041-90-1/Angiotensin I; EC

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