Document Detail

Blood pressure dynamics during pregnancy and spontaneous preterm birth.
MedLine Citation:
PMID:  17689635     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of the study was to examine whether blood pressure in early pregnancy and its rise in the second half of gestation are associated with spontaneous preterm birth in healthy, normotensive, nulliparous women.
STUDY DESIGN: We included 5167 women with singleton gestation who participated in the World Health Organization Calcium Supplementation for the Prevention of Preeclampsia Trial. Systolic, diastolic, and mean arterial blood pressure and pulse pressure at baseline (12-19 weeks of gestation) and at the midthird trimester (30-34 weeks) were calculated. Rise in blood pressure was the difference between the midthird trimester and baseline. Preterm birth was defined as early preterm (less than 34 completed weeks) and late preterm birth (34-36 weeks).
RESULTS: Women experiencing early or late preterm birth had over 10 mm Hg and 3 mm Hg higher rise, respectively, in systolic, diastolic, and mean arterial blood pressure than women delivering at term. A rise in systolic pressure over 30 mm Hg or diastolic pressure over 15 mm Hg was associated with a statistically significant 2- to 3-fold increase in risk of spontaneous preterm birth.
CONCLUSION: An excessive rise in either systolic or diastolic blood pressures from early pregnancy to the midthird trimester is associated with spontaneous preterm birth in a dose-response pattern.
Jun Zhang; Jose Villar; Wenyu Sun; Mario Merialdi; Hany Abdel-Aleem; Matthews Mathai; Mohamed Ali; Kai F Yu; Nelly Zavaleta; Manorama Purwar; Thi Nhu Ngoc Nguyen; Liana Campodonico; Sihem Landoulsi; Marshall Lindheimer; Guillermo Carroli
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  197     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-10     Completed Date:  2007-08-23     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  162.e1-6     Citation Subset:  AIM; IM    
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
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MeSH Terms
Blood Pressure
Cohort Studies
Pre-Eclampsia / physiopathology
Premature Birth / ethnology,  etiology*
Risk Factors
Grant Support
NIH0010199548//PHS HHS

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