Document Detail


Blood pressure, dementia and Alzheimer's disease: the OPTIMA longitudinal study.
MedLine Citation:
PMID:  19648748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: Studies on the relation between blood pressure (BP), dementia and Alzheimer's disease (AD) have yielded inconsistent results, showing an association with high or low BP, or no association with BP. The study was designed to look at the longitudinal effect of BP on cognitive function. METHODS: Participants were part of the OPTIMA longitudinal study of patients with dementia and agematched cognitively healthy controls. The Cambridge Cognitive Examination (CAMCOG) and BP were measured. We tested the dependence of CAMCOG scores on BP using generalised linear mixed models. RESULTS: A total of 235 were cognitively healthy controls, 42 had mild cognitive impairment (MCI), 141 had AD, and 59 had other dementia syndrome (ODS). In AD patients, the rate of decline of CAMCOG scores showed an inverted U-shaped (non-linear) dependence on diastolic BP. High (110 mm Hg) and low (60 mm Hg) levels of diastolic BP were related to faster cognitive decline over 5 years of follow-up (z = -2.51, p = 0.012). CAMCOG scores also showed an inverted U-shaped dependence on pulse pressure (z = -2.29, p = 0.022). CONCLUSION: High and low BP levels are related to faster cognitive decline in AD patients. This could have implications for the prevention and treatment of AD.
Authors:
George Razay; Jonathan Williams; Elizabeth King; A David Smith; Gordon Wilcock
Related Documents :
8792198 - Postprandial ambulatory blood pressure and heart rate effects in healthy elderly adults.
3672268 - Hypertension management in a cape peninsula coloured community. a retrospective medium-...
19644388 - Time rate of blood pressure variation is associated with impaired renal function in hyp...
6679238 - Systolic hypertension. direct and indirect bp measurements.
7476738 - Hemodynamic and oxygenation variables during radical cystectomy. does the anesthetic te...
15207398 - Blood pressure variability and cognitive function in older hypertensives.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-31
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  28     ISSN:  1421-9824     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-28     Completed Date:  2009-11-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  70-4     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Affiliation:
Dementia Research Centre, Launceston General Hospital, University of Tasmania, Launceston, Tas., Australia. george.razay@dhhs.tas.gov.au
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / physiopathology*
Antihypertensive Agents / therapeutic use
Blood Pressure / physiology*
Cognition / physiology
Cognition Disorders / physiopathology
Dementia / physiopathology*
Female
Humans
Hypertension / complications,  drug therapy
Longitudinal Studies
Male
Middle Aged
Neuropsychological Tests
Sex Characteristics
Grant Support
ID/Acronym/Agency:
//Department of Health
Chemical
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparison of methods for evaluating mineral loss: hardness versus synchrotron microcomputed tomogra...
Next Document:  Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades late...