Document Detail

Blood pressure, dementia and Alzheimer's disease: the OPTIMA longitudinal study.
MedLine Citation:
PMID:  19648748     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Studies on the relation between blood pressure (BP), dementia and Alzheimer's disease (AD) have yielded inconsistent results, showing an association with high or low BP, or no association with BP. The study was designed to look at the longitudinal effect of BP on cognitive function. METHODS: Participants were part of the OPTIMA longitudinal study of patients with dementia and agematched cognitively healthy controls. The Cambridge Cognitive Examination (CAMCOG) and BP were measured. We tested the dependence of CAMCOG scores on BP using generalised linear mixed models. RESULTS: A total of 235 were cognitively healthy controls, 42 had mild cognitive impairment (MCI), 141 had AD, and 59 had other dementia syndrome (ODS). In AD patients, the rate of decline of CAMCOG scores showed an inverted U-shaped (non-linear) dependence on diastolic BP. High (110 mm Hg) and low (60 mm Hg) levels of diastolic BP were related to faster cognitive decline over 5 years of follow-up (z = -2.51, p = 0.012). CAMCOG scores also showed an inverted U-shaped dependence on pulse pressure (z = -2.29, p = 0.022). CONCLUSION: High and low BP levels are related to faster cognitive decline in AD patients. This could have implications for the prevention and treatment of AD.
George Razay; Jonathan Williams; Elizabeth King; A David Smith; Gordon Wilcock
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-31
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  28     ISSN:  1421-9824     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-28     Completed Date:  2009-11-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  70-4     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Dementia Research Centre, Launceston General Hospital, University of Tasmania, Launceston, Tas., Australia.
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MeSH Terms
Alzheimer Disease / physiopathology*
Antihypertensive Agents / therapeutic use
Blood Pressure / physiology*
Cognition / physiology
Cognition Disorders / physiopathology
Dementia / physiopathology*
Hypertension / complications,  drug therapy
Longitudinal Studies
Middle Aged
Neuropsychological Tests
Sex Characteristics
Grant Support
//Department of Health
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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