| Blood pressure cosegregates with a microsatellite of angiotensin I converting enzyme (ACE) in F2 generation from a cross between original normotensive Wistar-Kyoto rat (WKY) and stroke-prone spontaneously hypertensive rat (SHRSP). | |
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MedLine Citation:
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PMID: 1662504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the linkage between high blood pressure and the ACE gene in the F2 generation between SHRSP/Izm and WKY/Izm. The male F2 rats were categorized into 3 genotypes according to a microsatellite polymorphism in the ACE gene. Significantly high blood pressure was observed in the SHRSP homozygotes when it was compared to the blood pressure of the heterozygotes. Further, after 2 or 3 months salt-loading, the blood pressure was significantly higher in the SHRSP homozygotes than in the heterozygotes and the WKY homozygotes. The heterozygotes had a blood pressure similar to that in the WKY homozygotes, indicating that the effect of the ACE gene genotype was recessive. Salt appetite was neither correlated with the salt-sensitivity nor cosegregated with the ACE genotype. The results indicate that the locus of ACE gene associates with the development of hypertension, especially salt-sensitive hypertension. |
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Authors:
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Y Nara; T Nabika; K Ikeda; M Sawamura; J Endo; Y Yamori |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 181 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-02-07 Completed Date: 1992-02-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 941-6 Citation Subset: IM |
Affiliation:
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Department of Pathology, Shimane Medical University, Izumo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite Blood Pressure* Crosses, Genetic DNA Fingerprinting Female Genotype Heterozygote Detection Homozygote Linkage (Genetics)* Male Peptidyl-Dipeptidase A / genetics* Polymerase Chain Reaction / methods Polymorphism, Genetic Rats Rats, Inbred SHR / genetics* Rats, Inbred WKY / genetics* Sodium, Dietary |
| Chemical | |
Reg. No./Substance:
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0/Sodium, Dietary; EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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