| Blood pressure control in patients receiving bevacizumab in an outpatient cancer center. | |
| | |
MedLine Citation:
|
PMID: 20817652 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
METHODS: A retrospective review of all patients who received bevacizumab between January 2007 and September 2009 at two medical centers was conducted. Patients were included if they experienced new onset or exacerbation of preexisting hypertension, during bevacizumab treatment. Efficacy of antihypertensives was determined by recording a 28-day change in systolic blood pressure from the initiation or dose increase of individual antihypertensive medications. Secondary endpoints included an efficacy analysis of antihypertensive classes. RESULTS: Five-hundred thirteen patients were identified as receiving bevacizumab during the indicated time period. Fifty-seven patients met the full inclusion/exclusion criteria for analysis. The average systolic blood pressure declined by 23 mm Hg with 4 weeks of treatment (p < 0.0001). Each class had a statistically significant decline in systolic blood pressure of 15.5-57 mm Hg with the exception of diuretics and a group of miscellaneous antihypertensives. CONCLUSIONS: This is the first data that demonstrates individual classes of antihypertensives are effective in bevacizumab-induced hypertension. Most antihypertensives were effective in reducing blood pressure, with the exception of diuretics and miscellaneous antihypertensives, which may be due to a limited sample size. |
| | |
Authors:
|
Sal Bottiglieri; Benyam Muluneh; Stephanie Sutphin; Lew Iacovelli; Val Adams |
Publication Detail:
|
Type: Journal Article Date: 2010-09-03 |
Journal Detail:
|
Title: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners Volume: 17 ISSN: 1477-092X ISO Abbreviation: J Oncol Pharm Pract Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-01 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9511372 Medline TA: J Oncol Pharm Pract Country: England |
Other Details:
|
Languages: eng Pagination: 333-8 Citation Subset: IM |
Affiliation:
|
UKHealthCare, University of Kentucky, Department of Pharmacy, 800 Rose Street, Room H110, Lexington, KY 40536, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of monotherapy and combined therapy with NSC-631570 (Ukrain) on growth of low- and high-m...
Next Document: Adding a physical exercise programme to brief intervention for low back pain patients did not increa...