Document Detail

Blood pressure control in kidney transplant recipients: influence of immunosuppression.
MedLine Citation:
PMID:  10385269     Owner:  NLM     Status:  MEDLINE    
1. Disturbances of the blood pressure regulation, probably due to dysfunction of the autonomic nervous system, are well known complications in chronic renal failure. Haemodialysis and transplantation have been reported to ameliorate nerve dysfunction. 2. In this study, the function of the blood pressure control was investigated in kidney transplant recipients after longtime haemodialysis treated with ciclosporine A and tacrolimus and compared to healthy individuals. To investigate the influence of immunosuppression, the measurements were performed twice, at low and high whole blood concentrations of ciclosporine and tacrolimus. Besides ciclosporine, tacrolimus, azathioprine and prednisolone no other drugs were used in the group of kidney transplant recipients. 3. Kidney transplant recipients (KTR) treated with ciclosporine showed reduced blood pressure and heart rate responses to the cardiovascular stress tests (head-up tilt and cold pressure test) under basal conditions. Two hours after ciclosporine application, the differences in the responses to cardiovascular stress tests between KTR and controls were significantly more pronounced. 4. Patients with tacrolimus immunosuppression showed a similar blood pressure and heart rate response under basal conditions. Two hours after drug application, the blood pressure response following orthostatism and heart rate response to the cold pressure test were significantly higher in tacrolimus treated patients. 5. Our results indicate, that kidney transplant recipients still express an altered function of the blood pressure control. Furthermore, ciclosporine A and tacrolimus seem to contribute to dysfunction of the blood pressure regulation by their own. Tacrolimus immunosuppression does not seem to offer advantages concerning the function of the blood pressure control as compared to ciclosporine A.
U Gerhardt; M Riedasch; H Hohage
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of autonomic pharmacology     Volume:  19     ISSN:  0144-1795     ISO Abbreviation:  J Auton Pharmacol     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-08-18     Completed Date:  1999-08-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8106455     Medline TA:  J Auton Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  49-54     Citation Subset:  IM; S    
Department of Medicine D, University of Münster, Germany.
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MeSH Terms
Blood Pressure / drug effects*
Cardiovascular System / drug effects
Cold Temperature / adverse effects
Cyclosporins / pharmacology
Exercise Test
Heart Rate / drug effects*
Hypertension / prevention & control*
Hypotension, Orthostatic / prevention & control
Immunosuppressive Agents / pharmacology*
Kidney Transplantation / adverse effects*
Tacrolimus / pharmacology
Reg. No./Substance:
0/Cyclosporins; 0/Immunosuppressive Agents; 109581-93-3/Tacrolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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