| Blood pressure control in the Hypertension in the Very Elderly Trial (HYVET). | |
| | |
MedLine Citation:
|
PMID: 21390056 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
To report blood pressure control in the Hypertension in the Very Elderly Trial, a placebo-controlled trial of hypertensive (systolic blood pressure (SBP) 160-199 mm Hg, diastolic blood pressure (DBP) <110 mm Hg) participants over the age of 80 years, given treatment in three steps: indapamide slow release 1.5 mg alone, indapamide plus 2 mg perindopril and indapamide plus 4 mg perindopril. The difference in control between participants with combined systolic and diastolic hypertension (SDH, DBP90 mm Hg) and those with isolated systolic hypertension (ISH, DBP<90 mm Hg) is determined together with the effects of increments in the treatment regimen. At 2 years, the active treatment lowered blood pressure by 16.5/6.9 mm Hg more than that on placebo in participants with SDH and by 19.3/4.8 mm Hg more in those with ISH. The 2-year falls in pressure on placebo alone were 13.2/8.5 mm Hg in SDH and 8.2/1.5 mm Hg in ISH participants. With full titration of active treatment, 62% of SDH participants achieved goal SBP (<150 mm Hg) by 2 years and 71% of those with ISH. The corresponding results for DBP control (<80 mm Hg) were 40 and 78%. The addition of active perindopril 2 mg roughly doubled the percentage controlled, as did increasing to 4 from 2 mg. Blood pressure control was good with ISH and better than with SDH. The fall in SBP accounted for the observed 30% reduction in strokes, but the 21% reduction in total mortality and 64% reduction in heart failure were greater than predicted.Journal of Human Hypertension advance online publication, 10 March 2011; doi:10.1038/jhh.2011.10. |
| | |
Authors:
|
C J Bulpitt; N S Beckett; R Peters; G Leonetti; V Gergova; R Fagard; L A Burch; W Banya; A E Fletcher |
Related Documents
:
|
2328596 - Effects of coenzyme q10 in hemorrhagic shock. 2492466 - Continuous transtracheal oxygen delivery during cardiopulmonary resuscitation. an alter... 19217706 - Cerebral effects of three resuscitation protocols in uncontrolled haemorrhagic shock: a... 2790296 - Aortic input impedance during hypovolemic shock and after hyperosmotic solution infusion. 14699016 - Adenoviral transfer of endothelial nitric oxide synthase attenuates lesion formation in... 7398386 - Flow-volume curve contour in copd: correlation with pulmonary mechanics. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-10 |
Journal Detail:
|
Title: Journal of human hypertension Volume: - ISSN: 1476-5527 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Imperial College London, Hammersmith Campus, Care of the Elderly, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: State of the union between metabolism and the immune system in type 2 diabetes.
Next Document: Pulse pressure and systolic night-day ratio interact in prediction of macrovascular disease in patie...