Document Detail

Blood pressure control is hard to achieve in patients with chronic renal failure: results from a survey of renal units in Norway.
MedLine Citation:
PMID:  16127803     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the use of antihypertensive drugs and blood pressure (BP) levels in relation to current guidelines for BP control in patients with chronic renal failure (CRF). MATERIAL AND METHODS: A cross-sectional survey was carried out in six renal outpatient clinics in Oslo and the surrounding area. The hospital records of all renal patients not yet in need of renal replacement therapy and with serum creatinine>or=200 micromol/l who attended consultations with nephrologists regularly (at least every third month) were reviewed. RESULTS: Of the 351 patients, 97% had hypertension. the majority of patients (96%) were receiving antihypertensive therapy. The average number of antihypertensive drugs being taken was 2.7+/-1.3 (median 3), but it varied with the cause of CRF. The drugs most frequently prescribed as monotherapy were angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonists, which were used by 32%; 51% of patients were using three or more antihypertensive drugs. Loop diuretics were prescribed as monotherapy in 25% of cases and in combination with two or more other drugs in 87%. Age and serum creatinine levels influenced the choice of antihypertensive therapy. The target BP of <130/80 mmHg was obtained in 13% of patients, and lack of optimal BP control was mainly due to systolic hypertension. A total of 38% of patients had a BP of <140/90 mmHg, while 58% failed to achieve a systolic BP of <140 mmHg. CONCLUSION: Optimal blood pressure control is hard to achieve in patients with CRF, even with specialist care and the use of multiple antihypertensive drugs.
Line Katrine Prøsch; Marie Grøn Saelen; Helga Gudmundsdottir; Dagfinn Dyrbekk; Odd Helge Hunderi; Erik Arnesen; Dag Paulsen; Helge Skjønsberg; Ingrid Os
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of urology and nephrology     Volume:  39     ISSN:  0036-5599     ISO Abbreviation:  Scand. J. Urol. Nephrol.     Publication Date:  2005  
Date Detail:
Created Date:  2005-08-26     Completed Date:  2005-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0114501     Medline TA:  Scand J Urol Nephrol     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  242-8     Citation Subset:  IM    
Department of Pharmacotherapeutics, University of Oslo, Norway.
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MeSH Terms
Age Factors
Aged, 80 and over
Antihypertensive Agents / administration & dosage*
Cross-Sectional Studies
Drug Utilization
Hypertension / complications*,  physiopathology,  prevention & control*
Kidney Failure, Chronic / complications*,  physiopathology*,  therapy
Middle Aged
Retrospective Studies
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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