Document Detail

Blood pressure control and erythrocytosis in rats: theory and observations.
MedLine Citation:
PMID:  7954100     Owner:  NLM     Status:  MEDLINE    
We compared some of our latest experiments on blood pressure control and erythrocytosis in spontaneously hypertensive rats with Gaar's computer-simulated studies, which suggest that erythrocytosis is a key to understanding the hemodynamic changes in hypertension. We tested two of Gaar's several predictions: (i) peripheral vascular resistance decreases when the feedback control of erythrocytosis is blocked and (ii) in primary hypertension, blood volume is increased slightly. We also studied the interrelation of systolic blood pressure and plasma renin substrate in spontaneously hypertensive rats, and the effect of diet on renin, blood pressure, and erythrocytosis. Our data showed that (i) on a percentage basis the renin system supports blood pressure essentially in the same manner in normal and hypertensive rats, (ii) peripheral vascular resistance decreased when erythrocytosis was partially blocked by feeding a low-iron diet, (iii) blood volume was similar in normal and hypertensive rats, and (iv) dextrin stimulates plasma renin, packed cell volume, and blood pressure in hypertensive rats. We conclude that blood pressure and erythrocytosis are interrelated, that the combined data of stimulated and experimental studies support the notion that primary hypertension is a blood-vessel adaptation in response to a renal energy need that may require additional oxygen.
A B Gould; S Goodman; C Swartz
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  72     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-12-27     Completed Date:  1994-12-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  679-86     Citation Subset:  IM    
Department of Medicine, Hahnemann University, Philadelphia, PA.
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MeSH Terms
Aging / physiology
Angiotensinogen / blood
Blood Pressure / physiology*
Dextrins / pharmacology
Polycythemia / physiopathology*
Rats, Inbred SHR
Rats, Inbred WKY
Renin / blood
Vascular Resistance / physiology
Reg. No./Substance:
0/Dextrins; 11002-13-4/Angiotensinogen; EC

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