Document Detail

Blood pressure and cognitive function in older adults with cardiovascular disease.
MedLine Citation:
PMID:  19916851     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Past studies link elevated blood pressure (BP) and BP variability to adverse neurocognitive changes in community samples. However, little is known about the relationship between BP indices and cognitive function in older CVD patients.
METHODS: A total of 99 older adults with CVD completed a comprehensive neuropsychological test battery. Resting BP measurements were collected every 10 min for 2 hr during a separate cardiac assessment. Five BP indices were generated: average and standard deviation of systolic blood pressure (SBP), average and standard deviation of diastolic blood pressure (DBP), and a function of systolic variability and average diastolic pressure. We examined the relationship between these BP indices and cognitive function.
RESULTS: Partial correlation adjusting for age and education revealed that the function of systolic variability and average diastolic pressure (SBP standard deviation divided by the average DBP) was most closely related to test performance, showing significant associations to both Learning/Memory (r = 0.25) and Language functioning (r = 0.22). SBP indices were also related to Language functioning (SBP avg., r = 0.22; SBP SD, r = 0.25), though DBP indices were unrelated to performance in any cognitive domain.
CONCLUSIONS: The current findings indicate that BP is modestly related to cognitive function in older CVD patients. Contrary to expectations, greater BP variability was associated with better, not poorer, cognitive test performance. Such findings suggest that the relationship between BP and cognitive function is more complicated than typically believed and requires further examination.
John Gunstad; Therese Anne Keary; Mary Beth Spitznagel; Athena Poppas; Robert H Paul; Lawrence H Sweet; Karin F Hoth; Andreana P Haley; Daniel E Forman; Ronald A Cohen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  119     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-17     Completed Date:  2010-01-28     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2228-42     Citation Subset:  IM    
Department of Psychology, Kent State University, Kent, Ohio 44242, USA.
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MeSH Terms
Blood Pressure*
Cardiovascular Diseases / physiopathology*
Cluster Analysis
Cognition / physiology*
Longitudinal Studies
Neuropsychological Tests
Time Factors
Grant Support
F32 AG026850/AG/NIA NIH HHS; R01 DK075119-04/DK/NIDDK NIH HHS; R01 HL089311-04/HL/NHLBI NIH HHS

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