Document Detail

Blood pressure change in a free-living population-based dietary modification study in Japan.
MedLine Citation:
PMID:  16467647     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess whether dietary intervention in free-living healthy subjects is effective in improving blood pressure levels. DESIGN: Open randomised, controlled trial. SETTING: Free-living healthy subjects in two rural villages in north-eastern Japan. PARTICIPANTS: Five hundred and fifty healthy volunteers aged 40-69 years. INTERVENTIONS: Tailored dietary education to encourage a decrease in sodium intake and an increase in the intake of vitamin C and carotene, and of fruit and vegetables. MAIN OUTCOME MEASURES: Blood pressure, dietary intake and urinary excretion of sodium, dietary carotene and vitamin C, and fruit and vegetable intake data were collected at 1 year after the start of the intervention. RESULTS: During the first year, changes differed significantly between the intervention and control groups for dietary (P = 0.002) and urinary excretion (P < 0.001) of sodium and dietary vitamin C and carotene (P = 0.003). Systolic blood pressure decreased from 127.9 to 125.2 mmHg (2.7 mmHg decrease; 95% confidence interval, -4.6 to -0.8) in the intervention group, whereas it increased from 128.0 to 128.5 mmHg (0.5 increase; -1.3 to 2.3) in the control group. This change was statistically significant (P = 0.007). In contrast, the change in diastolic blood pressure did not significantly differ between the groups. In hypertensive subjects, a significant difference in systolic blood pressure reduction was seen between the groups (P = 0.032). CONCLUSION: Moderate-intensity dietary counseling in free-living healthy subjects achieved significant dietary changes, which resulted in a significant decrease in systolic blood pressure.
Yoshiko Takahashi; Satoshi Sasaki; Shunji Okubo; Masato Hayashi; Shoichiro Tsugane
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  24     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-09     Completed Date:  2006-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  451-8     Citation Subset:  IM    
Epidemiology and Prevention Division, Research Center for Cancer Prevention, Tokyo, Japan.
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MeSH Terms
Ascorbic Acid / administration & dosage
Blood Pressure*
Carotenoids / administration & dosage
Diet, Sodium-Restricted
Food Habits*
Hypertension / prevention & control*,  therapy
Life Style
Middle Aged
Sodium, Dietary / urine
Reg. No./Substance:
0/Sodium, Dietary; 36-88-4/Carotenoids; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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