| Blood pressure, C-reactive protein, and risk of future cardiovascular events. | |
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MedLine Citation:
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PMID: 14638538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Accumulating data suggest a link between blood pressure and vascular inflammation. METHODS AND RESULTS: We examined the relationship between blood pressure, C-reactive protein (CRP), and incident first cardiovascular events among 15 215 women followed prospectively over a median of 8.1 years. In cross-sectional analyses at baseline, median levels of CRP for women with blood pressure <120/75, 120 to 129/75 to 84, 130 to 139/85 to 89, 140 to 159/90 to 94, and > or =160/95 mm Hg were 0.96, 1.42, 2.20, 2.82, and 3.34 mg/L, respectively (P for trend <0.0001). Increasing categories of blood pressure were significant predictors of CRP levels at baseline. In prospective analyses, both elevated CRP levels (> or =3 mg/L) and increasing categories of blood pressure were independent determinants of future cardiovascular events, and CRP had incremental prognostic value at all levels of blood pressure. The adjusted hazard ratio for women with blood pressure > or =160/95 mm Hg and CRP levels > or =3 mg/L was 8.31 (95% CI, 4.44 to 15.55, P<0.0001) compared with those with blood pressure <120/75 and CRP levels <3 mg/L. After participants had been divided into 4 groups on the basis of CRP levels (<3 or > or =3 mg/L) and blood pressure levels (<130/85 or > or =130/85), the risk factor-adjusted hazard ratios were as follows: low CRP/low blood pressure, 1.0; high CRP/low blood pressure, 1.87 (P=0.002); low CRP/high blood pressure, 2.54 (P<0.0001); and high CRP/high blood pressure, 3.27 (P<0.0001). CONCLUSIONS: CRP and blood pressure are independent determinants of cardiovascular risk, and their predictive value is additive. |
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Authors:
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Gavin J Blake; Nader Rifai; Julie E Buring; Paul M Ridker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2003-11-24 |
Journal Detail:
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Title: Circulation Volume: 108 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-12-16 Completed Date: 2004-01-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 2993-9 Citation Subset: AIM; IM |
Affiliation:
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Center for Cardiovascular Disease Prevention and the Donald W. Reynolds Center for Cardiovascular Research, Boston, Mass, USA. gblake@mater.ie |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure* C-Reactive Protein / analysis* Cardiovascular Diseases / epidemiology* Cross-Sectional Studies Disease-Free Survival Female Humans Incidence Middle Aged Prospective Studies Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL-43851/HL/NHLBI NIH HHS; HL-58755/HL/NHLBI NIH HHS; HL-63293/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
Erratum In:
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Circulation. 2007 May 22;115(20):e537 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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