Document Detail


Blood platelets and biological response to 'danger' signals - and subsequent inflammation: Towards a new paradigm?
MedLine Citation:
PMID:  21444230     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Blood platelets are cellular elements of primary haemostasis. During the last decade research on platelets has been subsequently based on this paradigm, with separate observations on issues such as the ability for platelets to bind infectious agents or even engulf them, to drop in counts in case of evolving infectious processes, etc. More recently, novel work has set up bases for novel functions for platelets, as members of functional immune cells, principally in innate immunity but capable of influencing adaptive immunity. Platelets are thus essential to haemostasis and to inflammation, questioning their essential functionality and the set up of a novel paradigm: could platelets be tissue-repairing cells? Such an assumption would open an entire new field of investigations. The present "State of the Art" essay attempts to discuss the main arguments on this.
Authors:
O Garraud; P Damien; J Berthet; C-A Arthaud; H Hamzeh-Cognasse; F Cognasse
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-26
Journal Detail:
Title:  Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine     Volume:  -     ISSN:  1953-8022     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423846     Medline TA:  Transfus Clin Biol     Country:  -    
Other Details:
Languages:  FRE     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
Affiliation:
EFS Auvergne-Loire Saint-Étienne, 25, boulevard Pasteur, 42023 Saint-Étienne cedex 2, France; Université de Lyon, 42023 Saint-Étienne, France; Faculté de médecine, université Jean-Monnet Saint-Étienne, 15, rue Ambroise-Paré, 42023 Saint-Étienne, France; Gimap EA3064, 15, rue Ambroise-Paré, 42023 Saint-Étienne, France.
Vernacular Title:
Plaquettes sanguines, réponses aux signaux de danger infectieux et inflammation : vers un nouveau paradigme ?
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